Association of maternal depression and hypothyroidism with infant gastroschisis: a population-based cohort study in Canada

Gastroschisis has increased globally over recent decades, and this increase has not been explained by identified risk factors. We conducted a population-based study of infants born in Canada, 2004–2020. We used “ winter ” months (i.e., September through June) and northern areas of residence as indic...

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Bibliographic Details
Published in:Scientific reports 2023-05, Vol.13 (1), p.7540-13, Article 7540
Main Authors: Liu, Shiliang, Claude, Hughes, Yong, Shin Jie, Chen, Dunjin
Format: Article
Language:English
Subjects:
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Canada - epidemiology
Child, Preschool
Cohort analysis
Cohort Studies
Depression
Diabetes mellitus
Female
Gastroschisis - epidemiology
Growth Hormone
Hormones
Humanities and Social Sciences
Humans
Hypothyroidism
Hypothyroidism - complications
Hypothyroidism - epidemiology
Infant
Infants
Mental depression
multidisciplinary
Offspring
Population studies
Population-based studies
Pregnancy
Risk factors
Science
Science (multidisciplinary)
Substance use
Summer
Thermoregulation
Tobacco smoking
Winter
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Summary:Gastroschisis has increased globally over recent decades, and this increase has not been explained by identified risk factors. We conducted a population-based study of infants born in Canada, 2004–2020. We used “ winter ” months (i.e., September through June) and northern areas of residence as indicators of less sunlight/less active lifestyle, while “summer” (i.e., July and August) and southern areas were considered as reference. Rate of gastroschisis for infants conceived in winter (3.4 per 10,000) was higher than for infants conceived in summer (2.2 per 10,000; p  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-34090-2