Extracellular volume fraction measurement correlates with lymphocyte abundance in thymic epithelial tumors

Recent advance in tissue characterization with parametric mapping imaging has the potential to be a novel biomarker for histopathologic correlation with thymic epithelial tumors (TETs). The purpose of our study is to evaluate MRI T1 mapping with the calculation of extracellular volume (ECV) fraction...

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Bibliographic Details
Published in:Cancer imaging 2020-10, Vol.20 (1), p.71-71, Article 71
Main Authors: Chang, Chao-Chun, Lin, Chia-Ying, Chu, Chang-Yao, Hsiung, Yi-Cheng, Chuang, Ming-Tsung, Tseng, Yau-Lin, Yen, Yi-Ting
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Cancer
Child
Classification
Clinical outcomes
Correlation analysis
Epithelial tumors
Extracellular space
Female
Humans
Lymphocytes
Lymphocytes - pathology
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Magnetic Resonance Imaging - standards
Male
Mapping
Mathematical analysis
Measurement
Medical research
Middle Aged
Myasthenia gravis
Neoplasms, Glandular and Epithelial - diagnostic imaging
Neoplasms, Glandular and Epithelial - pathology
Patients
Pulmonary arteries
Statistical analysis
Thoracic surgery
Thymic epithelial tumor (TET)
Thymoma - diagnostic imaging
Thymoma - pathology
Thymus Neoplasms - diagnostic imaging
Thymus Neoplasms - pathology
Tumors
World Health Organization (WHO)
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Summary:Recent advance in tissue characterization with parametric mapping imaging has the potential to be a novel biomarker for histopathologic correlation with thymic epithelial tumors (TETs). The purpose of our study is to evaluate MRI T1 mapping with the calculation of extracellular volume (ECV) fraction for histologic correlation with thymic epithelial tumor based on lymphocyte abundance. A retrospective study including 31 consecutive patients (14 men and 17 women, median age, 56 years; interquartile range, 12 years) with TETs was performed. The T1 values and ECV were assessed by using quantitative MRI mapping techniques. Mann-Whitney U test, Kruskal-Wallis H test, and receiver operating characteristic curve analyses were used to assess discrimination between different types of TETs based on lymphocyte abundance. Extracellular volume was significantly higher in TETs with sparse lymphocyte, including type A, type B3, and thymic carcinoma, compared with those with abundant lymphocyte, including type B1, B2, and AB thymomas (42.5% vs 26.9%, respectively; p 
ISSN:1470-7330
1740-5025
1470-7330
DOI:10.1186/s40644-020-00349-4