Regulatory Effects of Maternal Intake of Microbial-Derived Antioxidants on Colonization of Microbiota in Breastmilk and That of Intestinal Microbiota in Offspring

In this study, sixteen Sprague Dawley (SD) female rats and eight SD male rats were co-housed to mate. Pregnant SD female rats were fed with a control diet or an MA diet. Breast milk, maternal ileum, and intestinal samples of the offspring were collected at the day of birth and ten days afterwards. T...

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Bibliographic Details
Published in:Animals (Basel) 2024-09, Vol.14 (17), p.2582
Main Authors: Wu, Dangjin, An, Ran, Wang, Di, Jiang, Luoxin, Huang, Liu, Lu, Tenghui, Xu, Weina, Xu, Jianxiong, Zhang, Jing
Format: Article
Language:English
Subjects:
Antioxidants
Biotechnology
breast milk
breastmilk microbiota
colostrum
Diet
Females
genus
Hogs
ileum
intestinal microorganisms
Laboratory animals
Lactobacillus
Lactococcus
males
maternal feed
Microbiota
milk
offspring gut microbiota
Oxidative stress
Pregnancy
progeny
Pseudomonas veronii
rat
Small intestine
Weaning
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Summary:In this study, sixteen Sprague Dawley (SD) female rats and eight SD male rats were co-housed to mate. Pregnant SD female rats were fed with a control diet or an MA diet. Breast milk, maternal ileum, and intestinal samples of the offspring were collected at the day of birth and ten days afterwards. The results showed that the impact of MA was more obvious on the microbiota of mature milk ( = 0.066) than on that of colostrum. In addition, MA additive did not significantly affect maternal ileal microbiota, but affected offsprings' colonic microbiota significantly ten days after birth ( = 0.035). From the day of giving birth to ten days afterwards, in addition to the increase in microbial richness and diversity, at genus level, the dominant bacteria of breastmilk changed from to and . Different from breastmilk microbiota, ten days after giving birth, the maternal ileal microbiota and the offsprings' intestinal microbiota were dominated by . Instead of ileal microbiota, offsprings' colonic microbiota is a key action site of maternal MA additive. Therefore, the current findings have significant implications for the development of maternal feed aimed at modulating the intestinal microbiota of offspring, ultimately leading to improved health outcomes for both mothers and their offspring.
ISSN:2076-2615
2076-2615
DOI:10.3390/ani14172582