Decreased Expression of Angiotensin II Type 1 and Type 2 Receptors in the Brain After Long-Term Administration of Antihypertensive Drugs in Stroke-Prone Spontaneously Hypertensive Rat

The present study examined the levels of Angiotensin II type 1 receptor (AT1) and type 2 receptor (AT2) in the brain stem and cerebral cortex of the stroke-prone spontaneously hypertensive rat (SHR-sp) after long-term treatment with three types of antihypertensive drugs: valsartan, enalapril, and am...

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Bibliographic Details
Published in:Journal of Pharmacological Sciences 2008, Vol.106(4), pp.663-666
Main Authors: Nishida, Yayoi, Takahashi, Yasuo, Sugahara-Kobayashi, Megumi, Ishikawa, Kouichi, Asai, Satoshi
Format: Article
Language:English
Subjects:
Amlodipine - pharmacology
angiotensin II receptor
Angiotensin II Type 1 Receptor Blockers - pharmacology
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Animals
Antihypertensive Agents - pharmacology
antihypertensive drug
Blood Pressure - drug effects
brain
Brain Stem - drug effects
Brain Stem - metabolism
Calcium Channel Blockers - pharmacology
Cerebral Cortex - drug effects
Cerebral Cortex - metabolism
Disease Models, Animal
Down-Regulation
Enalapril - pharmacology
Hypertension - complications
Hypertension - drug therapy
Hypertension - metabolism
Hypertension - physiopathology
Male
Rats
Rats, Inbred SHR
Receptor, Angiotensin, Type 1 - drug effects
Receptor, Angiotensin, Type 1 - genetics
Receptor, Angiotensin, Type 1 - metabolism
Receptor, Angiotensin, Type 2 - drug effects
Receptor, Angiotensin, Type 2 - genetics
Receptor, Angiotensin, Type 2 - metabolism
RNA, Messenger - metabolism
Stroke - etiology
Stroke - metabolism
Stroke - physiopathology
Stroke - prevention & control
Tetrazoles - pharmacology
Time Factors
Valine - analogs & derivatives
Valine - pharmacology
Valsartan
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Summary:The present study examined the levels of Angiotensin II type 1 receptor (AT1) and type 2 receptor (AT2) in the brain stem and cerebral cortex of the stroke-prone spontaneously hypertensive rat (SHR-sp) after long-term treatment with three types of antihypertensive drugs: valsartan, enalapril, and amlodipine. In both tissues, expression of the AT1was decreased by administration of each drug. Expression of the AT2was decreased in the cerebral cortex by drug administration, but did not change in the brain stem. This study may contribute to elucidating the relationship between AT1and AT2expressions and the effect of antihypertensive drugs in SHR-sp brain.
ISSN:1347-8613
1347-8648
DOI:10.1254/jphs.SC0080027