Identification of novel antiviral of fungus-derived brefeldin A against dengue viruses

Microbial natural products possess a wide range of biological and biochemical potential. Among them, fungal secondary metabolites are one of the most important sources for discovering new drugs or lead compounds. In the present study, we explored substances produced by the strain sp. FKI-7127 for it...

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Bibliographic Details
Published in:Tropical medicine and health 2017-10, Vol.45 (1), p.32-32, Article 32
Main Authors: Raekiansyah, Muhareva, Mori, Mihoko, Nonaka, Kenichi, Agoh, Masanobu, Shiomi, Kazuro, Matsumoto, Atsuko, Morita, Kouichi
Format: Article
Language:English
Subjects:
Adsorption
Antigens
Antiviral
Brefeldin A
Dengue fever
Dengue virus
Drug development
Encephalitis
Fungus
Infections
Metabolites
Morphology
Natural products
NMR
Nuclear magnetic resonance
Secondary metabolite
Short Report
Zika virus
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Summary:Microbial natural products possess a wide range of biological and biochemical potential. Among them, fungal secondary metabolites are one of the most important sources for discovering new drugs or lead compounds. In the present study, we explored substances produced by the strain sp. FKI-7127 for its antiviral activity. We identified brefeldin A as a novel antiviral agent against dengue viruses. The inhibitory effect of brefeldin A was confirmed by virus titer and immunofluorescence assay. Brefeldin A inhibited dengue viruses regardless of serotypes and other related viruses including Zika virus and Japanese encephalitis virus. Time-of-addition study showed that brefeldin A exerts its antiviral effect at an early stage of the dengue virus (DENV) life cycle. These studies demonstrate that (i) brefeldin A could be used as a lead compound for drug development of anti-DENV and other related viruses and (ii) fungal metabolites are a potential and valuable source for dengue virus drug discovery.
ISSN:1348-8945
1349-4147
1349-4147
DOI:10.1186/s41182-017-0072-7