Pathological characterization of lung fibrosis in Sprague-Dawley rats treated with fluoro-edenite fibres by intrapleural injection

An increased incidence of pleural mesotheliomas in Biancavilla (Italy) was attributed to the environmental exposure to fluoro-edenite (FE). Results from the Ramazzini Institute (RI) in vivo long-term study confirmed the evidence that exposure to FE fibres is correlated with an increase of malignant...

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Bibliographic Details
Published in:Journal of occupational medicine and toxicology (London, England) England), 2024-12, Vol.19 (1), p.45-10
Main Authors: Tibaldi, Eva, Gnudi, Federica, Mandrioli, Daniele, Bruno, Caterina, Zona, Amerigo, Fazzo, Lucia, Comba, Pietro
Format: Article
Language:English
Subjects:
Amphiboles
Ashcroft quantification
Fibrosis
Fluoro-Edenite
Health aspects
Immunohistochemistry
Mesothelioma
Methods
Physiological aspects
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Summary:An increased incidence of pleural mesotheliomas in Biancavilla (Italy) was attributed to the environmental exposure to fluoro-edenite (FE). Results from the Ramazzini Institute (RI) in vivo long-term study confirmed the evidence that exposure to FE fibres is correlated with an increase of malignant pleural mesotheliomas in Sprague-Dawley rats. Recently asbestosis-like features were substantiated in Biancavilla residents without known occupational exposures. Aim of this work was to establish whether FE induce lung fibrosis with a pathogenetic mechanism similar to other asbestiform fibres. Original slides from the RI study were systematically re-examined to characterize the FE-induced lesions. Quantitative analysis of lung fibrosis was assessed following the Ashcroft method. Immunohistochemical analysis of protein involved in fibrotic responses and histochemical staining for FE-fibres identification were performed. Like asbestos, FE caused fibrotic lesions, pleural plaques or nodules and mesotheliomas. A significant increase of lung fibrosis (p 
ISSN:1745-6673
1745-6673
DOI:10.1186/s12995-024-00434-5