Use of Amniotic Membrane in MMC-Augmented Trabeculectomy: A Retrospective Comparative Study

Amniotic membrane transplantation (AMT) has shown promising results as an antifibrotic agent in trabeculectomy. We aimed to evaluate the additional effect of AMT in MMC-augmented trabeculectomy. This retrospective study analyzed the results of the first 12 postoperative months of glaucomatous eyes s...

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Bibliographic Details
Published in:Clinical ophthalmology (Auckland, N.Z.) N.Z.), 2021-01, Vol.15, p.4527-4533
Main Authors: Roque, Joana, Vaz, Fernando Trancoso, Basto, Rita, Henriques, Susana, Lopes, Ana Sofia, Silva, Diana, Santos, Jorge, Pires, Graça, Lisboa, Maria, Prieto, Isabel
Format: Article
Language:English
Subjects:
amniotic membrane
antifibrotics
Antihypertensive drugs
Antihypertensives
Comparative analysis
Glaucoma
mitomycin c
Original Research
Ostomy
Polyvinyl alcohol
scarring
Statistical analysis
Success
Surgery
Sutures
trabeculectomy
Transplants & implants
Wound healing
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Summary:Amniotic membrane transplantation (AMT) has shown promising results as an antifibrotic agent in trabeculectomy. We aimed to evaluate the additional effect of AMT in MMC-augmented trabeculectomy. This retrospective study analyzed the results of the first 12 postoperative months of glaucomatous eyes submitted to Moorfields Safer Surgery Trabeculectomy with MMC alone (non-AMT group) compared to MMC and AMT (AMT group). Both groups were compared in terms of intraocular pressure (IOP), number of antihypertensive medications and need for surgical reinterventions. Absolute and relative success rates 12 months after surgery were defined as IOP
ISSN:1177-5467
1177-5483
1177-5483
DOI:10.2147/OPTH.S342593