Label-free detection of leukemic myeloblasts in hyaluronic acid

Chronic myeloid leukemia is generally required bone marrow biopsy for diagnosis. Although examining peripheral blood is less invasive, it has not been fully validated as a routine diagnostic test due to suboptimal sensitivity. To overcome this limitation, a number of methodologies based on microflui...

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Bibliographic Details
Published in:Journal of biological engineering 2022-11, Vol.16 (1), p.1-29, Article 29
Main Authors: Park, Suhyun, Kim, Hyueyun, Woo, Minna, Kim, Minsuk
Format: Article
Language:English
Subjects:
Analysis
Biopsy
Blood
Blood circulation
Bone marrow
Chronic myeloid leukemia
Digital cameras
Drug efficacy
Fluctuations
Hyaluronic acid
Invasiveness
Leukemia
Methodology
Microfluidic system
Microfluidics
Microscopy
Motion microscopy
Myeloid leukemia
Newtonian fluids
Non Newtonian fluids
Peripheral blood
Proteins
Sensitivity analysis
Shear stress
Tumor cells
Variance analysis
Vibration
Viscosity
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Summary:Chronic myeloid leukemia is generally required bone marrow biopsy for diagnosis. Although examining peripheral blood is less invasive, it has not been fully validated as a routine diagnostic test due to suboptimal sensitivity. To overcome this limitation, a number of methodologies based on microfluidics have been developed for sorting circulating tumor cells from peripheral blood of patients with leukemia.
ISSN:1754-1611
1754-1611
DOI:10.1186/s13036-022-00308-6