Low-Diversity Microbiota in Apical Periodontitis and High Blood Pressure Are Signatures of the Severity of Apical Lesions in Humans

(1) Background: In developed countries, the prevalence of apical periodontitis (AP) varies from 20% to 50% for reasons that could be associated with the apical periodontitis microbiota ecology. (2) Methods: We performed a clinical study in the Odontology department of Toulouse hospital in France, to...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2023-01, Vol.24 (2), p.1589
Main Authors: Minty, Matthieu, Lê, Sylvie, Canceill, Thibault, Thomas, Charlotte, Azalbert, Vincent, Loubieres, Pascale, Sun, Jiuwen, Sillam, Jonathan, Terce, François, Servant, Florence, Roulet, Alain, Ribiere, Céline, Ardouin, Michel, Mallet, Jean-Philippe, Burcelin, Rémy, Diemer, Franck, Georgelin-Gurgel, Marie, Blasco-Baque, Vincent
Format: Article
Language:English
Subjects:
apical periodontitis
Bacteria
Bacteria - genetics
Bacterial infections
Blood pressure
Granuloma
Granulomas
Gum disease
high blood pressure
Humans
Hypertension
Lesions
Microbiota
Microbiota - genetics
oral diseases
Oral hygiene
oral microbiome
Patients
periapical index
Periapical Periodontitis
Periodontitis
Relative abundance
Risk analysis
Risk factors
RNA, Ribosomal, 16S - genetics
rRNA 16S
Taxonomy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:(1) Background: In developed countries, the prevalence of apical periodontitis (AP) varies from 20% to 50% for reasons that could be associated with the apical periodontitis microbiota ecology. (2) Methods: We performed a clinical study in the Odontology department of Toulouse hospital in France, to sequence the 16S rRNA gene of AP microbiota and collect clinical parameters from 94 patients. Forty-four patients were characterized with a PAI (periapical index of AP severity) score lower or equal to 3, while the others had superior scores (n = 50). (3) Results: The low diversity of granuloma microbiota is associated with the highest severity (PAI = 5) of periapical lesions (Odds Ratio 4.592, IC 95% [1.6329; 14.0728]; = 0.001; notably, a lower relative abundance of Burkholderiaceae and a higher relative abundance of and ). We also identified that high blood pressure (HBP) is associated with the increase in PAI scores. (4) Conclusions: Our data show that a low diversity of bacterial ecology of the AP is associated with severe PAI scores, suggesting a causal mechanism. Furthermore, a second risk factor was blood pressure associated with the severity of apical periodontitis.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24021589