Effect of Systemic Lidocaine on Postoperative Early Recovery Quality in Patients Undergoing Supratentorial Tumor Resection

Lidocaine has been gradually used in general anesthesia. This study was designed to investigate the effect of systemic lidocaine on postoperative quality of recovery (QoR) in patients undergoing supratentorial tumor resection, and to explore its brain-injury alleviation effect in neurosurgical anest...

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Bibliographic Details
Published in:Drug design, development and therapy development and therapy, 2022-04, Vol.16, p.1171-1181
Main Authors: Zhao, Kai, Dong, Yushan, Su, Gaowei, Wang, Yaolin, Ji, Tao, Wu, Nanling, Cui, Xiaojie, Li, Wenzhan, Yang, Yanming, Chen, Xiuxia
Format: Article
Language:English
Subjects:
Adult
Analysis
Anesthesia
Anesthetics, Local
Atracurium
Brain
brain neoplasm
brain protection
Brain tumors
Dolasetron
Humans
Injuries
Interleukin-6
Interleukins
Lidocaine
Lidocaine - therapeutic use
Neurons
Original Research
Pain
postoperative pain
recovery quality
Remifentanil
Saline Solution
Sufentanil
Supratentorial Neoplasms - drug therapy
Supratentorial Neoplasms - surgery
supratentorial tumor resection
Tumor Necrosis Factor-alpha
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Summary:Lidocaine has been gradually used in general anesthesia. This study was designed to investigate the effect of systemic lidocaine on postoperative quality of recovery (QoR) in patients undergoing supratentorial tumor resection, and to explore its brain-injury alleviation effect in neurosurgical anesthesia. Sixty adult patients undergoing elective supratentorial tumor resection. Patients were randomly assigned either to receive lidocaine (Group L: 1.5 mg/kg bolus completed 10 min before anesthesia induction followed by an infusion at 2.0 mg/kg/h) or to receive normal saline (Group C: received volume-matched normal saline at the same infusion rate). Primary outcome measures were Quality of Recovery-40 (QoR-40) scores on postoperative day (POD) 1 and 2. Plasma concentrations of S100B protein (S100B), neuron specific enolase (NSE), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) before anesthesia induction and at the end of surgery were assessed. Visual Analogue Scale (VAS) scores were assessed at 1, 2, 6, 12, 24 and 48 h after surgery. Perioperative parameters and adverse events were also recorded. Patients between two groups had comparable baseline characteristics. Global QoR-40 scores on POD 1 and POD 2 were significantly higher (
ISSN:1177-8881
1177-8881
DOI:10.2147/DDDT.S359755