Multifaceted Roles of Adipose Tissue-Derived Exosomes in Physiological and Pathological Conditions

Adipose tissue functions importantly in the bodily homeostasis and systemic metabolism, while obesity links to multiple disorders. Beyond the canonical hormones, growth factors and cytokines, exosomes have been identified to play important roles in transmission of information from adipose tissue to...

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Bibliographic Details
Published in:Frontiers in physiology 2021-04, Vol.12, p.669429-669429
Main Authors: Liu, Yunnan, Wang, Chen, Wei, Mengying, Yang, Guodong, Yuan, Lijun
Format: Article
Language:English
Subjects:
adipose tissue
clinical application
exosomes
pathological functions
physiological functions
Physiology
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Summary:Adipose tissue functions importantly in the bodily homeostasis and systemic metabolism, while obesity links to multiple disorders. Beyond the canonical hormones, growth factors and cytokines, exosomes have been identified to play important roles in transmission of information from adipose tissue to other organs. Exosomes are nanoscale membrane vesicles secreted by donor cells, and transfer the genetic information to the recipient cells where the encapsulated nucleic acids and proteins are released. In this review, we elaborate the recent advances in the biogenesis and profiling of adipose tissue derived exosomes, and their physiological and pathological effects on different organs. Moreover, the potential significance of the exosomes as therapeutic vehicles or drugs is also discussed.
ISSN:1664-042X
1664-042X
DOI:10.3389/fphys.2021.669429