Antibacterial and Chemical Characterization of Silica-Quercetin-PEG Hybrid Materials Synthesized by Sol-Gel Route

• Published in: Molecules (Basel, Switzerland) Switzerland), 2022-02, Vol.27 (3), p.979
• Main Authors: Blanco, Ignazio, Latteri, Alberta, Cicala, Gianluca, D'Angelo, Antonio, Viola, Veronica, Arconati, Vincenzo, Catauro, Michelina
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; anti-bacterial properties; Antiinfectives and antibacterials; Bacteria; Bacteria - classification; Bacteria - drug effects; Biocompatible Materials - chemistry; Biomaterials; Biomedical materials; E coli; Flavonoids; Fourier transforms; FT-IR; hybrids materials; Infrared analysis; Infrared spectroscopy; Microbial Sensitivity Tests; Microscopy, Electron, Scanning; Morphology; Polyethylene glycol; Polyethylene Glycols - chemistry; Pseudomonas aeruginosa; Quercetin; Quercetin - chemistry; Scanning electron microscopy; SEM; Silica; Silicon Dioxide - chemistry; Sol-gel processes; sol–gel method; Spectroscopy, Fourier Transform Infrared; Spectrum analysis
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27030979

This paper aims to synthesize, via the sol-gel method, a biomaterial usable in the medical field. Here, the silica-PEG-quercetin system was evaluated in relation to the different concentrations of PEG (0, 6, 12, 24, 50 wt%) and quercetin (0, 5, 10, 15 wt%), respectively. In addition, Fourier Transform-Infrared spectroscopy (FT-IR), Scanning Electron Microscopy (SEM), and Kirby-Bauer analyses were performed. FT-IR was used to evaluate the hybrid formation and the influence of both PEG and Quercetin in the hybrid synthesized materials, SEM was used to evaluate the morphological properties, while the Kirby-Bauer test was used to understand the ability of the materials to inhibit the growth of the assayed bacterial strains , , , and ).