Transcriptome Analysis Reveals Genes Contributed to Min Pig Villi Hair Follicle in Different Seasons

The Min pig, a local pig breed in China, has a special trait which has intermittent villus and coat hair regeneration. However, the regulation and mechanism of villus in Min pigs have not yet been described. We observed and described the phenotype of Min pig dermal villi in detail and sequenced the...

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Published in:Veterinary sciences 2022-11, Vol.9 (11), p.639
Main Authors: Tian, Ming, He, Xinmiao, Wang, Wentao, Feng, Yanzhong, Zhang, Dongjie, Li, Zhongqiu, Liu, Di
Format: Article
Language:English
Subjects:
Adaptation
Animals
Cashmere
Cold
Desmosomes
DNA methylation
Evolution & development
Follicles
Genes
Genotype & phenotype
Hair
Hogs
Min pig
Morphogenesis
Phenotypes
season
Skin
Stem cells
Summer
Transcriptomes
villi hair follicle
Villus
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cited_by cdi_FETCH-LOGICAL-c458t-22a9600572a27bacf7f7d410001ca2483c7a77038f091009cd230a63e26f4e7c3
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container_issue 11
container_start_page 639
container_title Veterinary sciences
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creator Tian, Ming
He, Xinmiao
Wang, Wentao
Feng, Yanzhong
Zhang, Dongjie
Li, Zhongqiu
Liu, Di
description The Min pig, a local pig breed in China, has a special trait which has intermittent villus and coat hair regeneration. However, the regulation and mechanism of villus in Min pigs have not yet been described. We observed and described the phenotype of Min pig dermal villi in detail and sequenced the mRNA transcriptome of Min pig hair follicles. A total of 1520 differentially expressed genes (DEG) were obtained.K-means hierarchical clustering showed that there was a significant expression pattern difference in winter compared with summer. Gene enrichment and network analysis results showed that the hair growth in Min pigs was closely related to the composition of desmosomes and regulated by an interaction network composed of eight core genes, namely DSP, DSC3, DSG4, PKP1, TGM1, KRT4, KRT15, and KRT84. Methylation analysis of promoters of target genes showed that the PKP1 gene was demethylated. Our study will help to supplement current knowledge of the growth mechanism of different types of hair.
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subjects Adaptation
Animals
Cashmere
Cold
Desmosomes
DNA methylation
Evolution & development
Follicles
Genes
Genotype & phenotype
Hair
Hogs
Min pig
Morphogenesis
Phenotypes
season
Skin
Stem cells
Summer
Transcriptomes
villi hair follicle
Villus
title Transcriptome Analysis Reveals Genes Contributed to Min Pig Villi Hair Follicle in Different Seasons
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