Incidence of Secondary Hyperparathyroidism among Postmenopausal Women with End-Stage Knee Osteoarthritis

Purpose. To evaluate the incidence of secondary hyperparathyroidism (SH) among postmenopausal women with end-stage knee osteoarthritis scheduled for total knee replacement (TKR). Methods. 283 Caucasian postmenopausal women aged 49 to 81 (mean, 70) years with end-stage idiopathic knee osteoarthritis...

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Published in:Journal of orthopaedic surgery (Hong Kong) 2009-12, Vol.17 (3), p.310-312
Main Authors: Papavasiliou, Kyriakos A, Kenanidis, Eustathios I, Potoupnis, Michael E, Sarris, Ioannis K, Kirkos, John M, Kapetanos, George A
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biomarkers - blood
Bone density
Bones
Calcium - blood
Creatinine - blood
Female
Greece - epidemiology
Humans
Hyperparathyroidism, Secondary - epidemiology
Incidence
Middle Aged
Older people
Osteoarthritis, Knee - epidemiology
Osteoarthritis, Knee - surgery
Parathyroid Hormone - blood
Phosphorus - blood
Postmenopause
Regression Analysis
Vitamin D
Wound Healing
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Summary:Purpose. To evaluate the incidence of secondary hyperparathyroidism (SH) among postmenopausal women with end-stage knee osteoarthritis scheduled for total knee replacement (TKR). Methods. 283 Caucasian postmenopausal women aged 49 to 81 (mean, 70) years with end-stage idiopathic knee osteoarthritis were scheduled to undergo primary TKR. They had been menopausal for 7 to 31 (mean, 19) years. Their preoperative serum levels of intact parathyroid hormone (I-PTH), calcium, phosphorus, creatinine, and the clearance of creatinine were evaluated. Results. 100 patients had abnormally elevated serum I-PTH. The overall incidence of SH was 35%. Serum levels of calcium and phosphorus were elevated in 33 and 12 patients, respectively. The serum level of I-PTH correlated positively with patient age (r=0.158, p=0.008) and serum creatinine level (r=0.138, p=0.021) and negatively with clearance of creatinine (r= −0.169, p=0.004). Conclusion. SH is common among elderly postmenopausal women and may affect bone healing and implant fixation. Preoperative screening/evaluation of the serum PTH level in postmenopausal women scheduled for TKR is recommended.
ISSN:1022-5536
2309-4990
DOI:10.1177/230949900901700313