Combined Screening for Early Detection of Pre-Eclampsia

Although the precise pathophysiology of pre-eclampsia remains unknown, this condition continues to be a major cause of maternal and fetal mortality. Early prediction of pre-eclampsia would allow for timely initiation of preventive therapy. A combination of biophysical and biochemical markers are sup...

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Bibliographic Details
Published in:International journal of molecular sciences 2015-08, Vol.16 (8), p.17952-17974
Main Authors: Park, Hee Jin, Shim, Sung Shin, Cha, Dong Hyun
Format: Article
Language:English
Subjects:
biomarker
Biomarkers
Biomarkers - metabolism
cell-free fetal DNA
Deoxyribonucleic acid
DNA
DNA - metabolism
Early Diagnosis
early prediction
Female
Fetus - metabolism
Gestational Age
Humans
maternal risk factors
mean maternal arterial pressure
Medical screening
pre-eclampsia
Pre-Eclampsia - diagnosis
Pre-Eclampsia - pathology
Preeclampsia
Pregnancy
pregnancy-associated plasma protein-A (PAPP-A)
Review
Risk factors
ultrasound parameters
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Summary:Although the precise pathophysiology of pre-eclampsia remains unknown, this condition continues to be a major cause of maternal and fetal mortality. Early prediction of pre-eclampsia would allow for timely initiation of preventive therapy. A combination of biophysical and biochemical markers are superior to other tests for early prediction of the development of pre-eclampsia. Apart from the use of parameters in first-trimester aneuploidy screening, cell-free fetal DNA quantification is emerging as a promising marker for prediction of pre-eclampsia. This article reviews the current research of the most important strategies for prediction of pre-eclampsia, including the use of maternal risk factors, mean maternal arterial pressure, ultrasound parameters, and biomarkers.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms160817952