The association between abnormal coagulation testing in preeclampsia, adverse pregnancy outcomes, and placental histopathology

Objective: We aimed to determine whether abnormal coagulation laboratory testing results in preeclampsia, are associated with adverse pregnancy outcomes and placental histopathology lesions. Methods: Demographic, labor, laboratory-testing, and placental histopathology reports of pregnancies complica...

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Bibliographic Details
Published in:Hypertension in pregnancy 2019-07, Vol.38 (3), p.176-183
Main Authors: Feldstein, Ohad, Kovo, Michal, Tal, Ori, Braunstein, Michal, Grinstein, Ehud, Schreiber, Letizia, Bar, Jacob, Weiner, Eran
Format: Article
Language:English
Subjects:
Adult
Blood Coagulation - physiology
Blood Coagulation Tests
coagulation studies
Female
fibrinogen
Humans
Infant, Small for Gestational Age
Placenta - pathology
placental pathology
Pre-Eclampsia - blood
Pre-Eclampsia - pathology
Preeclampsia
Pregnancy
Pregnancy Outcome
pregnancy outcomes
Young Adult
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Summary:Objective: We aimed to determine whether abnormal coagulation laboratory testing results in preeclampsia, are associated with adverse pregnancy outcomes and placental histopathology lesions. Methods: Demographic, labor, laboratory-testing, and placental histopathology reports of pregnancies complicated by preeclampsia were compared between those with and without abnormal coagulation profile (ACP). Results: Of 348 cases of preeclampsia 16.1% had ACP. There were no differences between the groups in GA at delivery, severe features, placental-abruption, SGA, composite adverse neonatal outcome and placental histopathology lesions. Conclusion: ACP in pregnancies complicated by preeclampsia was not associated with any of the studied outcomes. Our data question the usefulness of routine coagulation tests in the initial assessment of women presenting with preeclampsia.
ISSN:1064-1955
1525-6065
DOI:10.1080/10641955.2019.1638396