Evaluation of Motor Complications in Parkinson’s Disease: Understanding the Perception Gap between Patients and Physicians

Background. Patients with Parkinson’s disease (PD) receiving levodopa treatment often report motor complications including wearing-off (WO), dyskinesia, and morning akinesia. As motor complications are associated with a decrease in patients’ quality of life (QoL), it is important to identify their o...

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Bibliographic Details
Published in:Parkinson's disease 2021-12, Vol.2021, p.1599477-8
Main Authors: Ogura, Hiromu, Nakagawa, Ryoko, Ishido, Miwako, Yoshinaga, Yoko, Watanabe, Jun, Kurihara, Kanako, Hayashi, Yuka, Nagaki, Koichi, Mishima, Takayasu, Fujioka, Shinsuke, Tsuboi, Yoshio
Format: Article
Language:English
Subjects:
Akinesia
Clinical medicine
Cooperation
Discordance
Dopa
Dyskinesia
Levodopa
Medical research
Medicine
Medicine, Experimental
Movement disorders
Neurodegenerative diseases
Parkinson's disease
Patients
Perception
Physicians
Practice
Quality of life
Questionnaires
Rankings
Self awareness
Self evaluation
Self-recognition
Surveys
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Summary:Background. Patients with Parkinson’s disease (PD) receiving levodopa treatment often report motor complications including wearing-off (WO), dyskinesia, and morning akinesia. As motor complications are associated with a decrease in patients’ quality of life (QoL), it is important to identify their occurrence and commence immediate management. This study investigated whether differences in the perception of motor complications exist between patients and their physicians in routine clinical practice. Methods. After an Internet-based screening survey, questionnaires were distributed to physicians and their patients in Japan. The 9-item Wearing-Off Questionnaire (WOQ-9) was used to objectively assess the presence of WO; patients with WOQ-9 scores ≥2 were considered to have WO. McNemar’s test was used to compare physician assessment versus WOQ-9 scores, patient self-awareness versus physician assessment, and patient self-awareness versus WOQ-9, separately. Morning akinesia and dyskinesia were assessed by both physician assessment and patient self-awareness with McNemar’s test. QoL was assessed using the 8-item Parkinson’s Disease Questionnaire (PDQ-8) with the Wilcoxon rank-sum test. Results. A total of 235 patients with PD and their 92 physicians participated in this survey. A significant discordance was observed between the WOQ-9 and physician assessment of WO (67.2% vs 46.0%; p
ISSN:2090-8083
2042-0080
DOI:10.1155/2021/1599477