Relationship between serum iron level and physical function in heart failure patients is lost by presence of diabetes

Aims Iron deficiency (ID) is common in patients with heart failure (HF) and is reportedly associated with exercise intolerance and impaired quality of life. Iron supplementation therapy in HF patients with ID improves exercise capacity. Conversely, protective roles of iron depletion in the developme...

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Bibliographic Details
Published in:ESC Heart Failure 2024-02, Vol.11 (1), p.513-523
Main Authors: Ohori, Katsuhiko, Yano, Toshiyuki, Katano, Satoshi, Nagaoka, Ryohei, Numazawa, Ryo, Yamano, Kotaro, Fujisawa, Yusuke, Kouzu, Hidemichi, Nagano, Nobutaka, Fujito, Takefumi, Nishikawa, Ryo, Ohwada, Wataru, Sato, Tatsuya, Furuhashi, Masato
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Anemia
Anemia, Iron-Deficiency - complications
Body mass index
Cardiovascular disease
Diabetes
Diabetes Mellitus
Ejection fraction
Female
Ferritins
Frailty
Gait
Heart failure
Heart Failure - diagnosis
Hemoglobin
Humans
Iron
Iron Deficiencies
Iron deficiency
Male
Malnutrition
Metabolism
Middle Aged
Mortality
Nutritional status
Original
Quality of Life
Regression analysis
Sarcopenia
Short physical performance battery
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Summary:Aims Iron deficiency (ID) is common in patients with heart failure (HF) and is reportedly associated with exercise intolerance and impaired quality of life. Iron supplementation therapy in HF patients with ID improves exercise capacity. Conversely, protective roles of iron depletion in the development of diabetes mellitus (DM) and its complications have been proposed. This study aimed to determine the impact of ID on physical function in HF patients with and without DM. Methods and results We enrolled consecutive patients who were admitted to our institute for HF diagnosis and management. The short physical performance battery (SPPB) was used to evaluate physical function, and low physical function was defined as an SPPB score of
ISSN:2055-5822
2055-5822
DOI:10.1002/ehf2.14610