Evaluation of body weight-based vancomycin therapy and the incidence of nephrotoxicity: a retrospective study in the northwest of China

Highlights • Associations between vancomycin treatment and nephrotoxicity were evaluated retrospectively in 90 patients in the northwest of China. • Fourteen (15.6%) patients developed nephrotoxicity, with serum creatinine elevated significantly from mean (standard deviation) 90.0 (18.8) μmol/l to 1...

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Bibliographic Details
Published in:International journal of infectious diseases 2015-08, Vol.37 (C), p.125-128
Main Authors: Dong, Mo-Han, Wang, Jing-Wen, Wu, Yin, Chen, Bei-Yu, Yu, Min, Wen, Ai-Dong
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - therapeutic use
Blood trough concentration
Body Weight
China
Female
Humans
Incidence
Infectious Disease
Kidney - drug effects
Kidney Diseases - epidemiology
Male
Methicillin-Resistant Staphylococcus aureus
Middle Aged
Nephrotoxicity
Pulmonary/Respiratory
Retrospective Studies
Risk factor
Risk Factors
Staphylococcal Infections - drug therapy
Vancomycin
Vancomycin - administration & dosage
Vancomycin - adverse effects
Vancomycin - blood
Vancomycin - therapeutic use
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Summary:Highlights • Associations between vancomycin treatment and nephrotoxicity were evaluated retrospectively in 90 patients in the northwest of China. • Fourteen (15.6%) patients developed nephrotoxicity, with serum creatinine elevated significantly from mean (standard deviation) 90.0 (18.8) μmol/l to 133.8 (63.2) μmol/l ( p = 0.015). • Drug dosing >38 mg/kg/day and a serum trough level >20 mg/l were identified as risk factors of nephrotoxicity. • The renal function of critically ill patients receiving vancomycin should be monitored closely.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2015.06.025