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Evaluation of body weight-based vancomycin therapy and the incidence of nephrotoxicity: a retrospective study in the northwest of China
Highlights • Associations between vancomycin treatment and nephrotoxicity were evaluated retrospectively in 90 patients in the northwest of China. • Fourteen (15.6%) patients developed nephrotoxicity, with serum creatinine elevated significantly from mean (standard deviation) 90.0 (18.8) μmol/l to 1...
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| Published in: | International journal of infectious diseases 2015-08, Vol.37 (C), p.125-128 |
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| Main Authors: | , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c521t-10bd155d5c2f1cb713f1e368235cfee03cf446e56ce71cb7485679f05b9f88933 |
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| cites | cdi_FETCH-LOGICAL-c521t-10bd155d5c2f1cb713f1e368235cfee03cf446e56ce71cb7485679f05b9f88933 |
| container_end_page | 128 |
| container_issue | C |
| container_start_page | 125 |
| container_title | International journal of infectious diseases |
| container_volume | 37 |
| creator | Dong, Mo-Han Wang, Jing-Wen Wu, Yin Chen, Bei-Yu Yu, Min Wen, Ai-Dong |
| description | Highlights • Associations between vancomycin treatment and nephrotoxicity were evaluated retrospectively in 90 patients in the northwest of China. • Fourteen (15.6%) patients developed nephrotoxicity, with serum creatinine elevated significantly from mean (standard deviation) 90.0 (18.8) μmol/l to 133.8 (63.2) μmol/l ( p = 0.015). • Drug dosing >38 mg/kg/day and a serum trough level >20 mg/l were identified as risk factors of nephrotoxicity. • The renal function of critically ill patients receiving vancomycin should be monitored closely. |
| doi_str_mv | 10.1016/j.ijid.2015.06.025 |
| format | article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-10bd155d5c2f1cb713f1e368235cfee03cf446e56ce71cb7485679f05b9f88933</citedby><cites>FETCH-LOGICAL-c521t-10bd155d5c2f1cb713f1e368235cfee03cf446e56ce71cb7485679f05b9f88933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1201971215001630$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3549,27924,27925,45780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26159843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dong, Mo-Han</creatorcontrib><creatorcontrib>Wang, Jing-Wen</creatorcontrib><creatorcontrib>Wu, Yin</creatorcontrib><creatorcontrib>Chen, Bei-Yu</creatorcontrib><creatorcontrib>Yu, Min</creatorcontrib><creatorcontrib>Wen, Ai-Dong</creatorcontrib><title>Evaluation of body weight-based vancomycin therapy and the incidence of nephrotoxicity: a retrospective study in the northwest of China</title><title>International journal of infectious diseases</title><addtitle>Int J Infect Dis</addtitle><description>Highlights • Associations between vancomycin treatment and nephrotoxicity were evaluated retrospectively in 90 patients in the northwest of China. • Fourteen (15.6%) patients developed nephrotoxicity, with serum creatinine elevated significantly from mean (standard deviation) 90.0 (18.8) μmol/l to 133.8 (63.2) μmol/l ( p = 0.015). • Drug dosing >38 mg/kg/day and a serum trough level >20 mg/l were identified as risk factors of nephrotoxicity. • The renal function of critically ill patients receiving vancomycin should be monitored closely.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - administration & dosage</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Anti-Bacterial Agents - blood</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Blood trough concentration</subject><subject>Body Weight</subject><subject>China</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infectious Disease</subject><subject>Kidney - drug effects</subject><subject>Kidney Diseases - epidemiology</subject><subject>Male</subject><subject>Methicillin-Resistant Staphylococcus aureus</subject><subject>Middle Aged</subject><subject>Nephrotoxicity</subject><subject>Pulmonary/Respiratory</subject><subject>Retrospective Studies</subject><subject>Risk factor</subject><subject>Risk Factors</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Vancomycin</subject><subject>Vancomycin - administration & dosage</subject><subject>Vancomycin - adverse effects</subject><subject>Vancomycin - blood</subject><subject>Vancomycin - therapeutic use</subject><issn>1201-9712</issn><issn>1878-3511</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9ks1u1DAUhSMEoqXwAiyQl2wy-Cd2EoSQqlGBSpVYAGvLsa87Dhl7sJ0peQJeG4cpXbBg5Svfcz7r3uOqeknwhmAi3owbNzqzoZjwDRYbTPmj6px0bVczTsjjUpdW3beEnlXPUhoxxo0Q3dPqjArC-65h59Wvq6OaZpVd8ChYNASzoDtwt7tcDyqBQUflddgv2nmUdxDVYUHKm7VGzmtnwGtYnR4Ouxhy-Om0y8tbpFCEHEM6gM7uCCjluaBPFORDzLs7SHl1bnfOq-fVE6umBC_uz4vq24err9tP9c3nj9fby5tac0pyTfBgCOeGa2qJHlrCLAEmOsq4tgCYads0ArjQ0K79puOi7S3mQ2-7rmfsoro-cU1QozxEt1dxkUE5-ecixFupYnZ6Aql6xgdjxABYN7qzyirDCRsA2MAo1oX1-sQ6xPBjLtPIvUsapkl5CHOSpMWMNoz2tEjpSarLSlIE-_A0wXINU45yDVOuYUosZAmzmF7d8-dhD-bB8je9Inh3EkDZ2NFBlEm7NRDjYll7Gcn9n__-H7uenHdaTd9hgTSGOfqShSQyUYnll_U7rb-JcFyIDLPfKhzH6w</recordid><startdate>20150801</startdate><enddate>20150801</enddate><creator>Dong, Mo-Han</creator><creator>Wang, Jing-Wen</creator><creator>Wu, Yin</creator><creator>Chen, Bei-Yu</creator><creator>Yu, Min</creator><creator>Wen, Ai-Dong</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20150801</creationdate><title>Evaluation of body weight-based vancomycin therapy and the incidence of nephrotoxicity: a retrospective study in the northwest of China</title><author>Dong, Mo-Han ; Wang, Jing-Wen ; Wu, Yin ; Chen, Bei-Yu ; Yu, Min ; Wen, Ai-Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-10bd155d5c2f1cb713f1e368235cfee03cf446e56ce71cb7485679f05b9f88933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - administration & dosage</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Anti-Bacterial Agents - blood</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Blood trough concentration</topic><topic>Body Weight</topic><topic>China</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infectious Disease</topic><topic>Kidney - drug effects</topic><topic>Kidney Diseases - epidemiology</topic><topic>Male</topic><topic>Methicillin-Resistant Staphylococcus aureus</topic><topic>Middle Aged</topic><topic>Nephrotoxicity</topic><topic>Pulmonary/Respiratory</topic><topic>Retrospective Studies</topic><topic>Risk factor</topic><topic>Risk Factors</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Vancomycin</topic><topic>Vancomycin - administration & dosage</topic><topic>Vancomycin - adverse effects</topic><topic>Vancomycin - blood</topic><topic>Vancomycin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong, Mo-Han</creatorcontrib><creatorcontrib>Wang, Jing-Wen</creatorcontrib><creatorcontrib>Wu, Yin</creatorcontrib><creatorcontrib>Chen, Bei-Yu</creatorcontrib><creatorcontrib>Yu, Min</creatorcontrib><creatorcontrib>Wen, Ai-Dong</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Directory of Open Access Journals</collection><jtitle>International journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Mo-Han</au><au>Wang, Jing-Wen</au><au>Wu, Yin</au><au>Chen, Bei-Yu</au><au>Yu, Min</au><au>Wen, Ai-Dong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of body weight-based vancomycin therapy and the incidence of nephrotoxicity: a retrospective study in the northwest of China</atitle><jtitle>International journal of infectious diseases</jtitle><addtitle>Int J Infect Dis</addtitle><date>2015-08-01</date><risdate>2015</risdate><volume>37</volume><issue>C</issue><spage>125</spage><epage>128</epage><pages>125-128</pages><issn>1201-9712</issn><eissn>1878-3511</eissn><abstract>Highlights • Associations between vancomycin treatment and nephrotoxicity were evaluated retrospectively in 90 patients in the northwest of China. • Fourteen (15.6%) patients developed nephrotoxicity, with serum creatinine elevated significantly from mean (standard deviation) 90.0 (18.8) μmol/l to 133.8 (63.2) μmol/l ( p = 0.015). • Drug dosing >38 mg/kg/day and a serum trough level >20 mg/l were identified as risk factors of nephrotoxicity. • The renal function of critically ill patients receiving vancomycin should be monitored closely.</abstract><cop>Canada</cop><pub>Elsevier Ltd</pub><pmid>26159843</pmid><doi>10.1016/j.ijid.2015.06.025</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of infectious diseases, 2015-08, Vol.37 (C), p.125-128 |
| issn | 1201-9712 1878-3511 |
| language | eng |
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| source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS; ScienceDirect® |
| subjects | Adult Aged Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - adverse effects Anti-Bacterial Agents - blood Anti-Bacterial Agents - therapeutic use Blood trough concentration Body Weight China Female Humans Incidence Infectious Disease Kidney - drug effects Kidney Diseases - epidemiology Male Methicillin-Resistant Staphylococcus aureus Middle Aged Nephrotoxicity Pulmonary/Respiratory Retrospective Studies Risk factor Risk Factors Staphylococcal Infections - drug therapy Vancomycin Vancomycin - administration & dosage Vancomycin - adverse effects Vancomycin - blood Vancomycin - therapeutic use |
| title | Evaluation of body weight-based vancomycin therapy and the incidence of nephrotoxicity: a retrospective study in the northwest of China |
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