Antidiabetic Phytochemicals From Medicinal Plants: Prospective Candidates for New Drug Discovery and Development

Diabetes, a chronic physiological dysfunction affecting people of different age groups and severely impairs the harmony of peoples' normal life worldwide. Despite the availability of insulin preparations and several synthetic oral antidiabetic drugs, there is a crucial need for the discovery an...

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Published in:Frontiers in endocrinology (Lausanne) 2022-02, Vol.13, p.800714-800714
Main Authors: Alam, Safaet, Sarker, Md Moklesur Rahman, Sultana, Taposhi Nahid, Chowdhury, Md Nafees Rahman, Rashid, Mohammad A, Chaity, Nusrat Islam, Zhao, Chao, Xiao, Jianbo, Hafez, Elsayed E, Khan, Shah Alam, Mohamed, Isa Naina
Format: Article
Language:English
Subjects:
antidiabetic
antihyperglycemic
bioactive compound
diabetes mellitus
Diabetes Mellitus - drug therapy
Drug Discovery
Endocrinology
Humans
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
phytochemical
Phytochemicals - pharmacology
Phytochemicals - therapeutic use
phytomedicine
Plants, Medicinal
Prospective Studies
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Summary:Diabetes, a chronic physiological dysfunction affecting people of different age groups and severely impairs the harmony of peoples' normal life worldwide. Despite the availability of insulin preparations and several synthetic oral antidiabetic drugs, there is a crucial need for the discovery and development of novel antidiabetic drugs because of the development of resistance and side effects of those drugs in long-term use. On the contrary, plants or herbal sources are getting popular day by day to the scientists, researchers, and pharmaceutical companies all over the world to search for potential bioactive compound(s) for the discovery and development of targeted novel antidiabetic drugs that may control diabetes with the least unwanted effects of conventional antidiabetic drugs. In this review, we have presented the prospective candidates comprised of either isolated phytochemical(s) and/or extract(s) containing bioactive phytoconstituents which have been reported in several , , and clinical studies possessing noteworthy antidiabetic potential. The mode of actions, attributed to antidiabetic activities of the reported phytochemicals and/or plant extracts have also been described to focus on the prospective phytochemicals and phytosources for further studies in the discovery and development of novel antidiabetic therapeutics.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2022.800714