Can myocardial work indices contribute to the exploration of patients with cardiac amyloidosis?

BackgroundCardiac amyloidosis (CA) is a life-threatening restrictive cardiomyopathy. Identifying patients with a poor prognosis is essential to ensure appropriate care. The aim of this study was to compare myocardial work (MW) indices with standard echocardiographic parameters in predicting mortalit...

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Bibliographic Details
Published in:Open heart 2020-10, Vol.7 (2), p.e001346
Main Authors: Roger-Rollé, Aénora, Cariou, Eve, Rguez, Khailène, Fournier, Pauline, Lavie-Badie, Yoan, Blanchard, Virginie, Roncalli, Jérôme, Galinier, Michel, Carrié, Didier, Lairez, Olivier
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Amyloidosis - diagnostic imaging
Amyloidosis - mortality
Amyloidosis - physiopathology
Biochemistry
Biopsy
Blood pressure
Cardiomyopathies - diagnostic imaging
Cardiomyopathies - mortality
Cardiomyopathies - physiopathology
Echocardiography, Doppler
Echocardiography, Stress
Ejection fraction
Exercise Test
Female
Heart Failure and Cardiomyopathies
Humans
Male
Medical prognosis
Middle Aged
Mortality
Myocardial Contraction
Observer Variation
Patients
Predictive Value of Tests
Prognosis
Reproducibility of Results
Retrospective Studies
Software
Stroke Volume
Ventricular Function, Left
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Summary:BackgroundCardiac amyloidosis (CA) is a life-threatening restrictive cardiomyopathy. Identifying patients with a poor prognosis is essential to ensure appropriate care. The aim of this study was to compare myocardial work (MW) indices with standard echocardiographic parameters in predicting mortality among patients with CA.MethodsClinical, biological and transthoracic echocardiographic parameters were retrospectively compared among 118 patients with CA. Global work index (GWI) was calculated as the area of left ventricular pressure–strain loop. Global work efficiency (GWE) was defined as percentage ratio of constructive work to sum of constructive and wasted works. Sixty-one (52%) patients performed a cardiopulmonary exercise.ResultsGWI, GWE, global longitudinal strain (GLS), left ventricular ejection fraction (LVEF) and myocardial contraction fraction (MCF) were correlated with N-terminal prohormone brain natriuretic peptide (R=−0.518, R=−0.383, R=−0.553, R=−0.382 and R=−0.336, respectively; p
ISSN:2053-3624
2398-595X
2053-3624
DOI:10.1136/openhrt-2020-001346