Sustained and Cost Effective Silver Substrate for Surface Enhanced Raman Spectroscopy Based Biosensing

While surface enhanced Raman spectroscopy (SERS) based biosensing has demonstrated great potential for point-of-care diagnostics in the laboratory, its application in the field is limited by the short life time of commonly used silver based SERS active substrates. In this work, we report our attempt...

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Bibliographic Details
Published in:Scientific reports 2017-07, Vol.7 (1), p.6917-11, Article 6917
Main Authors: Ju, Jian, Liu, Wei, Perlaki, Clint Michael, Chen, Keren, Feng, Chunhua, Liu, Quan
Format: Article
Language:English
Subjects:
140/133
631/1647/1888/2005
631/1647/527/1821
9/10
Biosensors
Chemoreception
Humanities and Social Sciences
Indoor environments
multidisciplinary
Nanoparticles
Nanotubes
Quantum dots
Raman spectroscopy
Science
Science (multidisciplinary)
Silver
Spectroscopy
Spectrum analysis
Substrates
Thin films
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Summary:While surface enhanced Raman spectroscopy (SERS) based biosensing has demonstrated great potential for point-of-care diagnostics in the laboratory, its application in the field is limited by the short life time of commonly used silver based SERS active substrates. In this work, we report our attempt towards SERS based field biosensing, involving the development of a novel sustained and cost-effective substrate composed of silver nanoparticles protected by small nitrogen-doped Graphene Quantum Dots, i.e. Ag NP@N-GQD, and its systematic evaluation for glucose sensing. The new substrate demonstrated significantly stronger Raman enhancement compared to pure silver nanoparticles. More importantly, the new substrate preserved SERS performance in a normal indoor environment for at least 30 days in both the wet and dry states, in contrast to only 10 days for pure silver nanoparticles. The Ag NP@N-GQD thin film in the dry state was then successfully applied as a SERS substrate for glucose detection in mouse blood samples. The new substrate was synthesized under mild experimental conditions, and the cost increase due to N-GQD was negligible. These results suggest that the Ag NP@N-GQD is a cost-effective and sustained SERS substrate, the development of which represents an important step towards SERS based field biosensing.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-07186-9