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Green synthesis of ZnO nanoparticles using Ficus palmata: Antioxidant, antibacterial and antidiabetic studies
•Zinc oxide nanoparticles (FP ZnO NPs) has been synthesized using extract of Ficus palmata and zinc acetate solution.•Its exhibited antioxidant and good antibacterial activity.•Showed better antidiabetic activity as compared to the plant extracts.•Improves the lipid profile.•Potential applications f...
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Published in: | Results in Chemistry 2022-01, Vol.4, p.100509, Article 100509 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •Zinc oxide nanoparticles (FP ZnO NPs) has been synthesized using extract of Ficus palmata and zinc acetate solution.•Its exhibited antioxidant and good antibacterial activity.•Showed better antidiabetic activity as compared to the plant extracts.•Improves the lipid profile.•Potential applications for therapeutic purposes.
Nanotechnology have paved the way for novel and more efficient methods for the treatment of various diseases like cancer and type 2 diabetes mellitus. In this study, the leaf extract of Ficus palmata was used as stabilizing and reducing agent for the synthesis of zinc oxide nanoparticles using zinc acetate solution. The prepared FP ZnO NPs were identified and characterized using UV–vis spectroscopy, Dynamic light scattering (DLS), Fourier transformed infrared spectroscopy (FTIR), Field emission scanning electron microscopy (FESEM), and Energy-dispersive spectrum (EDS). The green synthesized ZnO NPs by Ficus palmata (FP ZnONPs) were evaluated for their antioxidant, antimicrobial activity, and cytotoxicity against the human FR2 cell line. They exhibited antioxidant activity and good antibacterial activity against Staphylococcus aureus, Bacillus subtilus, Escherichia coli, Salmonella typhi, Klebsiella pneumoniae. Further, green synthesized FP ZnO NPs were also evaluated for in vitro and in vivo antidiabetic activity. The results showed that nanoparticles exhibit better antidiabetic activity as compared to the plant extracts. The percentage of inhibition for amylase and glucosidase was higher in FP ZnONPs. It was found to be 70.07 ± 0.07 µg/ml in amylase and 68.49 ± 0.43 µg/ml in the glucosidase inhibition assay. It also showed a significant (p |
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ISSN: | 2211-7156 2211-7156 |
DOI: | 10.1016/j.rechem.2022.100509 |