Toxicity, biodistribution and oxidative damage caused by zirconia nanoparticles after intravenous injection

As a promising nanomaterial for biomedical applications, zirconia nanoparticles (ZrO ) have aroused concern recently, but the toxicity of ZrO in vivo has received little attention. The aim of this study is to demonstrate the systematic single dose toxicity, biodistribution and oxidative damage of Zr...

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Bibliographic Details
Published in:International journal of nanomedicine 2019-01, Vol.14, p.5175-5186
Main Authors: Yang, Yue, Bao, Huihui, Chai, Qianqian, Wang, Zhiwen, Sun, Zhenning, Fu, Changhui, Liu, Zhaoping, Liu, Zhongjie, Meng, Xianwei, Liu, Tianlong
Format: Article
Language:English
Subjects:
Biochemistry
Biocompatibility
biodistribution
Biomedical engineering
Dentistry
Dosage and administration
Drug delivery systems
Drug dosages
EDTA
Experiments
Glucose
Hematology
Hemoglobin
ICP-OES
Laboratories
Liver
Macrophages
Medical research
Nanomaterials
Nanoparticles
Original Research
oxidative damage
Seeds
Spleen
Toxicity
Veins & arteries
White blood cell count
zirconia nanoparticles
Zirconium
Zirconium oxide
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Summary:As a promising nanomaterial for biomedical applications, zirconia nanoparticles (ZrO ) have aroused concern recently, but the toxicity of ZrO in vivo has received little attention. The aim of this study is to demonstrate the systematic single dose toxicity, biodistribution and oxidative damage of ZrO in vivo after intravenous injection in mice. Ten ICR mice were used at the high dose of ZrO including 600, 500, 400 and 300mg/kg. Maximum tolerated dose (MTD) of 150 nm ZrO was determined as 500mg/kg. Hematology analysis and blood biochemical assay were determined for the evaluation of oxidative damage caused by ZrO . Biodistribution of ZrO was investigated by ICP-OES and TEM. Mice treated with higher dose (500mg/kg) showed significant spread in white blood cell counts (
ISSN:1178-2013
1176-9114
1178-2013
DOI:10.2147/IJN.S197565