Neurologic Toxicity of Immune Checkpoint Inhibitors: A Review of Literature

Immune checkpoint inhibitors have entailed a change of paradigm in the management of multiple malignant diseases and are acquiring a key role in an increasing number of clinical sceneries. However, since their mechanism of action is not limited to the tumor microenvironment, their systemic activity...

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Bibliographic Details
Published in:Frontiers in pharmacology 2022-02, Vol.13, p.774170-774170
Main Authors: Albarrán, Víctor, Chamorro, Jesús, Rosero, Diana Isabel, Saavedra, Cristina, Soria, Ainara, Carrato, Alfredo, Gajate, Pablo
Format: Article
Language:English
Subjects:
checkpoint inhibitors
immunotherapy
neurologic
neuropathies
Pharmacology
toxicity
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Summary:Immune checkpoint inhibitors have entailed a change of paradigm in the management of multiple malignant diseases and are acquiring a key role in an increasing number of clinical sceneries. However, since their mechanism of action is not limited to the tumor microenvironment, their systemic activity may lead to a wide spectrum of immune-related side effects. Although neurological adverse events are much less frequent than gastrointestinal, hepatic, or lung toxicity, with an incidence of
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2022.774170