Study of Immunohistochemical Markers (CK-19, CD-56, Ki-67, p53) in Differentiating Benign and Malignant Solitary Thyroid Nodules with special Reference to Papillary Thyroid Carcinomas

Solitary Thyroid Nodule (STN) has provoked increased concern owing to higher incidence of malignancy. The inter and intra observer variation in the histomorphological diagnosis of Papillary Thyroid Carcinomas (PTC) may sometimes pose a diagnostic difficulty. This study was undertaken to analyse immu...

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Published in:Journal of clinical and diagnostic research 2016-12, Vol.10 (12), p.EC14-EC19
Main Authors: Dwivedi, Smriti Sudhanshu, Khandeparkar, Siddhi Gaurish Sinai, Joshi, Avinash R, Kulkarni, Maithili Mandar, Bhayekar, Pallavi, Jadhav, Amruta, Nayar, Musphera, Kambale, Neelam S
Format: Article
Language:English
Subjects:
cd 56
ck-19
follicular neoplasm
ihc
ki-67
p53
papillary thyroid carcinoma
Pathology Section
thyroid neoplasm
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Summary:Solitary Thyroid Nodule (STN) has provoked increased concern owing to higher incidence of malignancy. The inter and intra observer variation in the histomorphological diagnosis of Papillary Thyroid Carcinomas (PTC) may sometimes pose a diagnostic difficulty. This study was undertaken to analyse immunohistochemical (IHC) markers (CK-19, CD-56, p53, Ki-67) to differentiate between benign and malignant surgically resected STN along with their utility in the identification of PTC. The present cross sectional study was conducted over a period of 4 years. A technique of manual tissue array was employed for cases subjected to IHC. The primary antibodies used were CK-19, CD-56, p53 and Ki-67. Analysis of the expression of IHC markers (p53, Ki-67) to distinguish between benign and malignant STN was done. Evaluation and correlation of expression of IHC markers (CK-19, CD-56) to determine its utility in reaching definitive diagnosis and assessing prognosis of PTC was tried. Results were subjected to statistical analysis. The results were considered to be significant when the p-value
ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2016/22428.9114