Cloprostenol administration in the first week postpartum reduces expression of oxytocin receptors in the endometrium in Holstein-Zebu cows

ABSTRACT The present study investigated the hormonal profile and expression of prostaglandin F2α (PGF2α), oxytocin and estrogen receptors in uterine tissues of postpartum cows treated with cloprostenol. Twenty Holstein-Zebu crossbred cows were treated with saline solution (treatment CONT) or clopros...

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Bibliographic Details
Published in:Arquivo brasileiro de medicina veterinária e zootecnia 2017-08, Vol.69 (4), p.821-829
Main Authors: Camargos, A., Wohlres-Viana, S., Costa, I.F., Camargo, L.S., Ferreira, J.C., Ramos, A.A., Oba, E.
Format: Article
Language:English
Subjects:
ESR1
estradiol
progesterona
PTGFR
RT-PCR
VETERINARY SCIENCES
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Summary:ABSTRACT The present study investigated the hormonal profile and expression of prostaglandin F2α (PGF2α), oxytocin and estrogen receptors in uterine tissues of postpartum cows treated with cloprostenol. Twenty Holstein-Zebu crossbred cows were treated with saline solution (treatment CONT) or cloprostenol (treatment CLO), both administered two and five days postpartum. Blood samples were collected on days two, seven, 14, 21 and 28 postpartum for progesterone, PGF2α metabolite (PGFM) and estradiol determination, and endometrial biopsy was performed in order to quantify the expression of oxytocin receptor (OXTR), prostaglandin F receptor (PTGFR) and estrogen receptor 1 (ERS1) genes. In the CLO treatment, expression of OXTR was reduced (P0.05) between treatments was found for PTGFR and ERS1 expression. Estrogen concentrations increased progressively until day 14 (P
ISSN:0102-0935
1678-4162
0102-0935
DOI:10.1590/1678-4162-9318