Increases in Bdnf DNA Methylation in the Prefrontal Cortex Following Aversive Caregiving Are Reflected in Blood Tissue

Child maltreatment not only leads to epigenetic changes, but also increases the risk of related behavioral deficits and mental disorders. These issues presumably are most closely associated with epigenetic changes in the brain, but epigenetic changes in peripheral tissues like blood are often examin...

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Bibliographic Details
Published in:Frontiers in human neuroscience 2020-11, Vol.14, p.594244-594244
Main Authors: Duffy, Hannah B D, Roth, Tania L
Format: Article
Language:English
Subjects:
Bdnf
Behavior
Blood
Brain
Brain-derived neurotrophic factor
Child abuse & neglect
cross-tissue correlation
Deoxyribonucleic acid
DNA
DNA methylation
early-life stress
Epigenetics
Foster care
Gene expression
Human Neuroscience
Mental disorders
Prefrontal cortex
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Summary:Child maltreatment not only leads to epigenetic changes, but also increases the risk of related behavioral deficits and mental disorders. These issues presumably are most closely associated with epigenetic changes in the brain, but epigenetic changes in peripheral tissues like blood are often examined instead, due to their accessibility. As such, the reliability of using the peripheral epigenome as a proxy for that of the brain is imperative. Previously, our lab has found aberrant methylation at the ( ) gene in the prefrontal cortex of rats following aversive caregiving. The current study examined whether aversive caregiving alters DNA methylation in the blood compared to the prefrontal cortex. It was revealed that DNA methylation associated with adversity increased in both tissues, but this methylation was not correlated between tissues. These findings indicate that group trends in methylation between blood and the brain are comparable, but variation exists among individual subjects.
ISSN:1662-5161
1662-5161
DOI:10.3389/fnhum.2020.594244