Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris

Brain-derived neurotrophic factor (BDNF) is one of the proteins that contributes to the survival, growth, maintenance of neurons, and plays important roles in the pathophysiology of depression. It has been reported that depression is closely associated with the pathogenesis of acne vulgaris disease....

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Bibliographic Details
Published in:BMC psychiatry 2019-06, Vol.19 (1), p.193-193, Article 193
Main Authors: He, Hong-Yi, Tian, Jin-Lan, Deng, Yong-Qiong, Xiong, Xia, Xu, Yang, Liao, Yong-Mei, Fang, Jing, Feng, Xia, Ye, Xin, Li, Chang-Qiang
Format: Article
Language:English
Subjects:
Acne
Acne vulgaris
Acne Vulgaris - blood
Acne Vulgaris - diagnosis
Acne Vulgaris - epidemiology
Adolescent
Biomarkers - blood
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
China - epidemiology
Cross-Sectional Studies
Depression
Depression (Mood disorder)
Depression - blood
Depression - diagnosis
Depression - epidemiology
Enzyme-linked immunosorbent assay
Female
Health surveys
Humans
Insomnia
Interleukins
Male
Medical research
Necrosis
Neurons
Pathological physiology
Patient Health Questionnaire
Proteins
Regression analysis
Serum BDNF levels
Tumors
Young Adult
Youth
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Summary:Brain-derived neurotrophic factor (BDNF) is one of the proteins that contributes to the survival, growth, maintenance of neurons, and plays important roles in the pathophysiology of depression. It has been reported that depression is closely associated with the pathogenesis of acne vulgaris disease. But, there is no report of serum BDNF levels in patients with acne vulgaris. The study aimed to determine the potential association between BDNF and depressive symptoms in young adults with acne vulgaris. In this analytical cross-sectional study, the serum BDNF levels were measured in peripheral blood samples of 20 consecutive acne vulgaris patients with depression and 98 consecutive acne vulgaris patients without depression and also compared it with a 59 healthy control group by using a ELISA. The potential correlation between the BDNF levels, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), and depressive symptoms such as nine-item patient health questionnaire (PHQ-9) and Athens insomnia scale (AIS) were evaluated with multivariate logistic regression analysis. Our results showed that levels of BDNF expression were lower in consecutive acne vulgaris patients when compared with healthy control (P 
ISSN:1471-244X
1471-244X
DOI:10.1186/s12888-019-2182-8