Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris

Brain-derived neurotrophic factor (BDNF) is one of the proteins that contributes to the survival, growth, maintenance of neurons, and plays important roles in the pathophysiology of depression. It has been reported that depression is closely associated with the pathogenesis of acne vulgaris disease....

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Published in:BMC psychiatry 2019-06, Vol.19 (1), p.193-193, Article 193
Main Authors: He, Hong-Yi, Tian, Jin-Lan, Deng, Yong-Qiong, Xiong, Xia, Xu, Yang, Liao, Yong-Mei, Fang, Jing, Feng, Xia, Ye, Xin, Li, Chang-Qiang
Format: Article
Language:English
Subjects:
Acne
Acne vulgaris
Acne Vulgaris - blood
Acne Vulgaris - diagnosis
Acne Vulgaris - epidemiology
Adolescent
Biomarkers - blood
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
China - epidemiology
Cross-Sectional Studies
Depression
Depression (Mood disorder)
Depression - blood
Depression - diagnosis
Depression - epidemiology
Enzyme-linked immunosorbent assay
Female
Health surveys
Humans
Insomnia
Interleukins
Male
Medical research
Necrosis
Neurons
Pathological physiology
Patient Health Questionnaire
Proteins
Regression analysis
Serum BDNF levels
Tumors
Young Adult
Youth
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creator He, Hong-Yi
Tian, Jin-Lan
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Xu, Yang
Liao, Yong-Mei
Fang, Jing
Feng, Xia
Ye, Xin
Li, Chang-Qiang
description Brain-derived neurotrophic factor (BDNF) is one of the proteins that contributes to the survival, growth, maintenance of neurons, and plays important roles in the pathophysiology of depression. It has been reported that depression is closely associated with the pathogenesis of acne vulgaris disease. But, there is no report of serum BDNF levels in patients with acne vulgaris. The study aimed to determine the potential association between BDNF and depressive symptoms in young adults with acne vulgaris. In this analytical cross-sectional study, the serum BDNF levels were measured in peripheral blood samples of 20 consecutive acne vulgaris patients with depression and 98 consecutive acne vulgaris patients without depression and also compared it with a 59 healthy control group by using a ELISA. The potential correlation between the BDNF levels, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), and depressive symptoms such as nine-item patient health questionnaire (PHQ-9) and Athens insomnia scale (AIS) were evaluated with multivariate logistic regression analysis. Our results showed that levels of BDNF expression were lower in consecutive acne vulgaris patients when compared with healthy control (P 
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It has been reported that depression is closely associated with the pathogenesis of acne vulgaris disease. But, there is no report of serum BDNF levels in patients with acne vulgaris. The study aimed to determine the potential association between BDNF and depressive symptoms in young adults with acne vulgaris. In this analytical cross-sectional study, the serum BDNF levels were measured in peripheral blood samples of 20 consecutive acne vulgaris patients with depression and 98 consecutive acne vulgaris patients without depression and also compared it with a 59 healthy control group by using a ELISA. The potential correlation between the BDNF levels, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), and depressive symptoms such as nine-item patient health questionnaire (PHQ-9) and Athens insomnia scale (AIS) were evaluated with multivariate logistic regression analysis. Our results showed that levels of BDNF expression were lower in consecutive acne vulgaris patients when compared with healthy control (P &lt; 0.05). There was a negative correlation between levels of BDNF and the PHQ-9 scores (r = - 0.486, P &lt; 0.001). Furthermore, acne vulgaris patients with depression showed lower serum BDNF levels (10.96 ± 2.12 ng/ml) compared with acne vulgaris patients without depression (13.85 ± 2.47 ng/ml), as well as with healthy control (14.35 ± 2.70 ng/mg; both P &lt; 0.05). No difference was found in serum BDNF levels between healthy control and acne vulgaris patients without depressive symptoms (z = 0.964, P &gt; 0.05). Similarly, the overall area under the curve of receiver operating characteristic was 0.82, indicating the highly conserving of serum BDNF levels as an biomarker for screening of depression in young adults with acne vulgaris (72% sensitivity and 85% specificity). 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Our results showed that levels of BDNF expression were lower in consecutive acne vulgaris patients when compared with healthy control (P &lt; 0.05). There was a negative correlation between levels of BDNF and the PHQ-9 scores (r = - 0.486, P &lt; 0.001). Furthermore, acne vulgaris patients with depression showed lower serum BDNF levels (10.96 ± 2.12 ng/ml) compared with acne vulgaris patients without depression (13.85 ± 2.47 ng/ml), as well as with healthy control (14.35 ± 2.70 ng/mg; both P &lt; 0.05). No difference was found in serum BDNF levels between healthy control and acne vulgaris patients without depressive symptoms (z = 0.964, P &gt; 0.05). Similarly, the overall area under the curve of receiver operating characteristic was 0.82, indicating the highly conserving of serum BDNF levels as an biomarker for screening of depression in young adults with acne vulgaris (72% sensitivity and 85% specificity). 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It has been reported that depression is closely associated with the pathogenesis of acne vulgaris disease. But, there is no report of serum BDNF levels in patients with acne vulgaris. The study aimed to determine the potential association between BDNF and depressive symptoms in young adults with acne vulgaris. In this analytical cross-sectional study, the serum BDNF levels were measured in peripheral blood samples of 20 consecutive acne vulgaris patients with depression and 98 consecutive acne vulgaris patients without depression and also compared it with a 59 healthy control group by using a ELISA. The potential correlation between the BDNF levels, interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), and depressive symptoms such as nine-item patient health questionnaire (PHQ-9) and Athens insomnia scale (AIS) were evaluated with multivariate logistic regression analysis. Our results showed that levels of BDNF expression were lower in consecutive acne vulgaris patients when compared with healthy control (P &lt; 0.05). There was a negative correlation between levels of BDNF and the PHQ-9 scores (r = - 0.486, P &lt; 0.001). Furthermore, acne vulgaris patients with depression showed lower serum BDNF levels (10.96 ± 2.12 ng/ml) compared with acne vulgaris patients without depression (13.85 ± 2.47 ng/ml), as well as with healthy control (14.35 ± 2.70 ng/mg; both P &lt; 0.05). No difference was found in serum BDNF levels between healthy control and acne vulgaris patients without depressive symptoms (z = 0.964, P &gt; 0.05). Similarly, the overall area under the curve of receiver operating characteristic was 0.82, indicating the highly conserving of serum BDNF levels as an biomarker for screening of depression in young adults with acne vulgaris (72% sensitivity and 85% specificity). Serum BDNF levels were decreased and negatively associated with depressive symptoms in young Chinese adults with acne vulgaris.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>31234814</pmid><doi>10.1186/s12888-019-2182-8</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects Acne
Acne vulgaris
Acne Vulgaris - blood
Acne Vulgaris - diagnosis
Acne Vulgaris - epidemiology
Adolescent
Biomarkers - blood
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
China - epidemiology
Cross-Sectional Studies
Depression
Depression (Mood disorder)
Depression - blood
Depression - diagnosis
Depression - epidemiology
Enzyme-linked immunosorbent assay
Female
Health surveys
Humans
Insomnia
Interleukins
Male
Medical research
Necrosis
Neurons
Pathological physiology
Patient Health Questionnaire
Proteins
Regression analysis
Serum BDNF levels
Tumors
Young Adult
Youth
title Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris
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