Inflammation and nerve injury minimally affect mouse voluntary behaviors proposed as indicators of pain

Highlights • Inflammation suppressed wheel running and locomotion, and impaired gait in mice. • Nerve injury gave rise to gait deficits that are likely motor-, not pain-related. • Changes in wheel running or gait were unrelated to the degree of hypersensitivity. • Neither inflammation nor nerve inju...

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Bibliographic Details
Published in:Neurobiology of pain 2017-08, Vol.2, p.1-12
Main Authors: Sheahan, Tayler D, Siuda, Edward R, Bruchas, Michael R, Shepherd, Andrew J, Mohapatra, Durga P, Gereau, Robert W, Golden, Judith P
Format: Article
Language:English
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Pain Medicine
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Summary:Highlights • Inflammation suppressed wheel running and locomotion, and impaired gait in mice. • Nerve injury gave rise to gait deficits that are likely motor-, not pain-related. • Changes in wheel running or gait were unrelated to the degree of hypersensitivity. • Neither inflammation nor nerve injury altered social interactions or anxiety-like behavior.
ISSN:2452-073X
2452-073X
DOI:10.1016/j.ynpai.2017.09.001