Porphyria Cutanea Tarda Associated With Acute Hemorrhagic Pancreatitis

Porphyria cutanea tarda (PCT) is a condition of dysregulated heme synthesis that leads to accumulation of photosensitizing precursors with resultant fragility and blistering of the skin. It can be hereditary or acquired and has been known to be associated with hepatic C virus, alcohol, HIV, and estr...

Full description

Saved in:
Bibliographic Details
Published in:JIM - high impact case reports 2019-01, Vol.7, p.2324709619852769-2324709619852769
Main Authors: Singh, Manasi, Duckett, Ashley, Heincelman, Marc
Format: Article
Language:English
Subjects:
Blister - pathology
Case Report
Case reports
Humans
Male
Middle Aged
Pancreatitis
Pancreatitis, Acute Hemorrhagic - diagnosis
Pancreatitis, Acute Hemorrhagic - etiology
Porphyria Cutanea Tarda - complications
Porphyria Cutanea Tarda - diagnosis
Porphyria Cutanea Tarda - physiopathology
Risk Factors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Porphyria cutanea tarda (PCT) is a condition of dysregulated heme synthesis that leads to accumulation of photosensitizing precursors with resultant fragility and blistering of the skin. It can be hereditary or acquired and has been known to be associated with hepatic C virus, alcohol, HIV, and estrogen. In this article, we report an unusual presentation of PCT associated with acute hemorrhagic pancreatitis in a 57-year-old man. He presented initially to a community hospital with acute onset of epigastric abdominal pain and new-onset ascites. Lipase was elevated. Diagnostic paracentesis was grossly bloody. He was then transferred to our institution for concern for acute hemorrhagic pancreatitis. On arrival, physical examination demonstrated vesicles and bullae with erythematous bases, in different stages of healing seen over the dorsal aspects of both hands with scaling, scarring, and hypopigmentation and hyperpigmentation of the skin. Laboratory evaluation and skin biopsy confirmed the diagnosis of PCT. Search for an underlying etiology failed to reveal typical predisposing factors. This report illustrates that acute hemorrhagic pancreatitis may be an underlying etiology for PCT.
ISSN:2324-7096
2324-7096
DOI:10.1177/2324709619852769