Impact of neoadjuvant chemotherapy in improving operative intervention in the management of cervical cancer in low resource setting: a preliminary report

There is paucity of data on interventions to improve cancer outcome in the low-resource setting. This study aims to determine the effect of Neoadjuvant Chemotherapy (NACT) in improving operative outcomes of cervical cancer. This was a longitudinal intervention study of patients diagnosed with FIGO s...

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Bibliographic Details
Published in:The Pan African medical journal 2020, Vol.36 (210), p.210-210
Main Authors: Nwankwo, Theophilus Ogochukwu, Umeh, Uchenna Anthony, Aniebue, Uzochukwu Uzoma, Onu, Justus Uchenna, Umeh, Chioma Roseline
Format: Article
Language:English
Subjects:
Aged
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
cancer
cervical
chemotherapy
Chemotherapy, Adjuvant
Female
Humans
hysterectomy
Longitudinal Studies
Middle Aged
neoadjuvant
Neoadjuvant Therapy
Neoplasm Staging
Nigeria
Prospective Studies
radical
Short Communication
Treatment Outcome
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - therapy
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Summary:There is paucity of data on interventions to improve cancer outcome in the low-resource setting. This study aims to determine the effect of Neoadjuvant Chemotherapy (NACT) in improving operative outcomes of cervical cancer. This was a longitudinal intervention study of patients diagnosed with FIGO stage IIB - IIIA cervical cancer that had NACT. Patients were re-evaluated after treatment with 4 cycles of chemotherapy for operability. McNemar test was used to determine changes in operability of the tumour. There was a significant difference in the number of patients that converted from inoperable to operable tumor post-chemotherapy. This study shows some promise for NACT for FIGO stage IIB - IIIA cancer of the cervix, especially in low-resource settings, where radiotherapy is scarce.
ISSN:1937-8688
1937-8688
DOI:10.11604/pamj.2020.36.210.24141