Per- and Polyfluoroalkyl (PFAS) Disruption of Thyroid Hormone Synthesis

Per- and polyfluoroalkyl substances (PFAS) are a group of environmental pollutants that have been linked to a variety of health problems in humans, including the disruption of thyroid functions. Herein, for the first time, the impact of PFAS on thyroid hormone synthesis is shown. Mid- to long-chain...

Full description

Saved in:
Bibliographic Details
Published in:ACS omega 2024-09, Vol.9 (38), p.39554-39563
Main Authors: Bali, Semiha Kevser, Martin, Rebecca, Almeida, Nuno M. S., Saunders, Catherine, Wilson, Angela K.
Format: Article
Language:English
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Per- and polyfluoroalkyl substances (PFAS) are a group of environmental pollutants that have been linked to a variety of health problems in humans, including the disruption of thyroid functions. Herein, for the first time, the impact of PFAS on thyroid hormone synthesis is shown. Mid- to long-chain PFAS impact thyroid hormone synthesis by changing the local hydrogen bond network as well as the required orientation of hormonogenic residues, stopping the production of thyroxine (T4). Furthermore, the toxic effects of sulfonic PFAS are more prominent than those of carboxylic PFAS, highlighting that the exposure to these specific compounds can pose greater problems for thyroid homeostasis.
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.4c03578