PD-L1 Expression Correlated with p53 Expression in Pediatric Glioblastoma Multiforme

High-grade gliomas are infrequent in the pediatric population compared to adults, nevertheless, mortality and morbidity caused by malignant gliomas in this group of patients remain significant. PD-L1 and PD-1 Immune checkpoints (IC) molecules maintain immunological balance between activation and sup...

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Bibliographic Details
Published in:Brain sciences 2021-02, Vol.11 (2), p.262
Main Authors: Litak, Jakub, Grajkowska, Wiesława, Szumiło, Justyna, Krukow, Paweł, Maciejewski, Ryszard, Roliński, Jacek, Grochowski, Cezary
Format: Article
Language:English
Subjects:
GBM
PD-L1
pediatric glioblastoma multiforme
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Summary:High-grade gliomas are infrequent in the pediatric population compared to adults, nevertheless, mortality and morbidity caused by malignant gliomas in this group of patients remain significant. PD-L1 and PD-1 Immune checkpoints (IC) molecules maintain immunological balance between activation and suppression. Eighteen patients with a histopathological diagnosis of pediatric glioblastoma multiforme (GBM, WHO IV) were studied. In total, PD-L1 expression was detected in 8 patients (44%). The molecular aspect of IC and immunotherapy targeted on PD-1/PD-L1 axis in pediatric population may be a promising adjuvant therapy in pediatric glioblastoma multiform treatment, however, this subject requires further investigation.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci11020262