Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models

Cancer is a widespread but dangerous disease that can strike anyone and is the second 1leading cause of death worldwide. Prostate cancer, in particular, is a prevalent cancer that occurs in men, and much research is being done on its treatment. Although chemical drugs are effective, they have variou...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-05, Vol.24 (11), p.9240
Main Authors: Jeong, Se Hyo, Kim, Hun Hwan, Park, Min Young, Bhosale, Pritam Bhagwan, Abusaliya, Abuyaseer, Won, Chung Kil, Park, Kwang Il, Kim, Eunhye, Heo, Jeong Doo, Kim, Hyun Wook, Ahn, Meejung, Seong, Je Kyung, Kim, Gon Sup
Format: Article
Language:English
Subjects:
African Americans
Androgens
Apoptosis
Cancer
cancer cell death
Cancer therapies
Care and treatment
Cell death
Cell growth
Chemotherapy
Classification
Drug development
Drugs
Flavones
Flavonoids
Health aspects
Hormones
Hyperplasia
Isoflavones
Mortality
Mutation
Natural products
Oncology, Experimental
Prostate cancer
Radiation
Review
Risk factors
Steroids
Tangeretin
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Summary:Cancer is a widespread but dangerous disease that can strike anyone and is the second 1leading cause of death worldwide. Prostate cancer, in particular, is a prevalent cancer that occurs in men, and much research is being done on its treatment. Although chemical drugs are effective, they have various side effects, and accordingly, anticancer drugs using natural products are emerging. To date, many natural candidates have been discovered, and new drugs are being developed as drugs to treat prostate cancer. Representative candidate compounds that have been studied to be effective in prostate cancer include apigenin, acacetin and tangeretin of the flavone family among flavonoids. In this review, we look at the effects of these three flavones on prostate cancer cells via apoptosis in vitro and in vivo. Furthermore, in addition to the existing drugs, we suggest the three flavones and their effectiveness as natural anticancer agents, a treatment model for prostate cancer.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24119240