Accumulation and Tissue Distribution of Dinophysitoxin-1 and Dinophysitoxin-3 in the Mussel Crenomytilus grayanus Feeding on the Benthic Dinoflagellate Prorocentrum foraminosum

A DTX-1-producing microalga, , from Peter the Great Bay, Sea of Japan, was fed to Gray's mussels, , for 12 days. An increase in DTX-1 and 7- -acyl-DTX-1 (DTX-3) was observed in the digestive gland, kidneys, and gills. The digestive gland accumulated 91-100% of DTX-1 + DTX-3; and kidneys and gil...

Full description

Saved in:
Bibliographic Details
Published in:Marine drugs 2017-10, Vol.15 (10), p.330
Main Authors: Kameneva, Polina A, Krasheninina, Ekaterina A, Slobodskova, Valentina V, Kukla, Sergey P, Orlova, Tatiana Yu
Format: Article
Language:English
Subjects:
Accumulation
alkaline comet assay
Animals
Bioaccumulation
Cells
Composition
Crenomytilus grayanus
Diarrhea - etiology
Dinoflagellida - metabolism
dinophysistoxin-1
dinophysistoxin-3
Drugs
DSTs accumulation
Feeding
Gastrointestinal Tract - metabolism
Genotoxicity
Gills
Gills - metabolism
Gonads
Humans
Japan
Kidney - metabolism
Kidneys
Mantle
Marine Toxins - pharmacology
Mollusks
Mussels
Mutagenicity Tests
Mytilidae - metabolism
Oceans and Seas
Okadaic Acid
Prorocentrum
Prorocentrum foraminosum
Pyrans - pharmacology
Seafood - toxicity
Seawater
Seawater - chemistry
Tissue
Tissue Distribution
Toxins
Uptake
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A DTX-1-producing microalga, , from Peter the Great Bay, Sea of Japan, was fed to Gray's mussels, , for 12 days. An increase in DTX-1 and 7- -acyl-DTX-1 (DTX-3) was observed in the digestive gland, kidneys, and gills. The digestive gland accumulated 91-100% of DTX-1 + DTX-3; and kidneys and gills accumulated, up to 8.5% and 4.3%, respectively. The kidneys had a distinctive pattern of toxin accumulation where the concentration of DTX-1 did not grow significantly after the eighth day of feeding, indicating the potential of DTX-1 elimination. The digestive gland and gills predominantly accumulated DTX-1, with a dramatic increase between Days 8 and 12. The DTX-3 content was highest in the digestive gland. The composition of DTX-3 in the acyl groups was similar for the digestive gland and kidneys, and did not change during feeding. The total toxin uptake of mussels exceeded the total toxin content from ingested cells by 2.4 times, showing that toxins may have accumulated from the seawater. This assumption needs to be further proved. The muscle, gonads, and mantle remained free of toxins. No genotoxic effect was observed in the gills and digestive gland.
ISSN:1660-3397
1660-3397
DOI:10.3390/md15100330