The Interplay between Cardiovascular Risk, Cardiovascular Events, and Disease Activity in Primary Sjögren's Syndrome: Is Uric Acid the Missing Link?

(1) Background: Uric acid is a well-known cardiovascular (CV) risk factor in the general population but its role in the setting of rheumatic diseases other than gout is unclear. (2) Methods: This is a retrospective study investigating a cohort of 105 pSS patients recording clinical, serological, and...

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Bibliographic Details
Published in:Nutrients 2023-03, Vol.15 (7), p.1563
Main Authors: Alunno, Alessia, Carubbi, Francesco, Mariani, Francesco Maria, Martini, Cecilia, Campanozzi, Elena, Ferri, Claudio
Format: Article
Language:English
Subjects:
Algorithms
Body mass index
Cardiology
Cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - etiology
cardiovascular risk
cerebrovascular disease
Cholesterol
Complications and side effects
Development and progression
Diabetes
Diet
Female
Gout
Health aspects
Health risks
Heart Disease Risk Factors
Heart failure
Humans
Hypertension
Inflammatory diseases
Kidney stones
Laboratories
Lung diseases
Lung Diseases, Interstitial - complications
Measurement
Mortality
Obesity
Population
Retrospective Studies
Rheumatism
Rheumatoid arthritis
Risk assessment
Risk Factors
Sjogren's syndrome
Sjogren's Syndrome - complications
Sjogren's Syndrome - epidemiology
Sjögren’s syndrome
Society
Uric Acid
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Summary:(1) Background: Uric acid is a well-known cardiovascular (CV) risk factor in the general population but its role in the setting of rheumatic diseases other than gout is unclear. (2) Methods: This is a retrospective study investigating a cohort of 105 pSS patients recording clinical, serological, and CV-related variables including adherence to the Mediterranean diet. (3) Results: We observed a strong relationship between disease activity, interstitial lung disease (ILD), and CV events. The association between ILD and CV events was dependent on higher SUA levels but independent of other traditional CV risk factors. All three cases of previous non-fatal stroke were reported by females aged
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15071563