Mechanisms of lung and diaphragmatic protection by high PEEP in obese COVID-19 ARDS: role of the body mass index

[...]the least obese subgroup did not experience work of breathing unloading and deteriorated lung mechanics, neuroventilatory coupling and respiratory drive, suggesting that lung overdistension was probably induced. Body mass index Pes : Esophageal pressure Pmus : Muscular pressure PTPmin : Pressur...

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Published in:Critical care (London, England) England), 2022-06, Vol.26 (1), p.1-182, Article 182
Main Authors: Pérez, Joaquin, Dorado, Javier Hernan, Navarro, Emiliano, Morais, Caio C. A, Accoce, Matías
Format: Article
Language:English
Subjects:
Acute respiratory distress syndrome
Artificial respiration
Body mass index
Complications and side effects
Coronaviruses
Correspondence
COVID-19
Critical care
Obesity
Risk factors
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Summary:[...]the least obese subgroup did not experience work of breathing unloading and deteriorated lung mechanics, neuroventilatory coupling and respiratory drive, suggesting that lung overdistension was probably induced. Body mass index Pes : Esophageal pressure Pmus : Muscular pressure PTPmin : Pressure–time product per minute ΔPLdyn : Peak dynamic driving transpulmonary pressure PaO2/FiO2 : Arterial oxygen pressure to inspired oxygen Pes/Ti: Esophageal pressure to neural inspiratory time VT/PTPbreath : Tidal volume-to-pressure–time product per breath CLdyn : Dynamic lung compliance n.s: Body mass index and risk for COVID-19–related hospitalization, intensive care unit admission, invasive mechanical ventilation, and death—United States, March–December 2020.
ISSN:1364-8535
1364-8535
1366-609X
1466-609X
DOI:10.1186/s13054-022-04051-8