Distinction of IgG4-related mastitis from breast cancer: a case report

Background Immunoglobulin (Ig) G4-related sclerosing disease is a pathological concept proposed in Japan during the early 2000s. This lesion-forming disease may exhibit characteristics of a systemic disease but often affects a single organ. To date, IgG4-related sclerosing disease in the mammary gla...

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Bibliographic Details
Published in:Surgical case reports 2019-07, Vol.5 (1), p.123-5, Article 123
Main Authors: Tsuda, Banri, Kumaki, Nobue, Ishida, Rie, Mizuno, Mari, Yokoyama, Kozue, Oshitanai, Risa, Terao, Mayako, Morioka, Toru, Okamura, Takuho, Saito, Yuki, Suzuki, Yasuhiro, Niikura, Naoki
Format: Article
Language:English
Subjects:
Biopsy
Breast cancer
Case Report
Case reports
Hospitals
IgG4-related mastitis
IgG4-related sclerosing disease
Immunoglobulins
Lymphatic system
Mammography
Medicine
Medicine & Public Health
Pancreatitis
Pathology
Steroid therapy
Surgery
Systemic diseases
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Summary:Background Immunoglobulin (Ig) G4-related sclerosing disease is a pathological concept proposed in Japan during the early 2000s. This lesion-forming disease may exhibit characteristics of a systemic disease but often affects a single organ. To date, IgG4-related sclerosing disease in the mammary gland, or IgG4-related mastitis (IgG4-RM), has rarely been reported. Case presentation Here, we describe the case of a female patient who was admitted to our hospital with the main complaints of left breast and axillary lymphadenopathy. A careful diagnostic imaging examination led to an initial suspicion of breast cancer. However, a needle biopsy led to a diagnosis of IgG4-RM. Subsequently, the patient was successfully treated with predonin. Conclusions The treatment requirements for breast cancer and IgG4-RM differ considerably. This is a good example of a case wherein unnecessary surgical treatment, which is indicated for breast cancer, was avoided by needle biopsy. Accordingly, the patient was appropriately treated with steroids following a correct diagnosis.
ISSN:2198-7793
2198-7793
DOI:10.1186/s40792-019-0681-y