Correlation between adolescent chronic emotional stress and incidence of adult cardiovascular disease in female rats

Association of adolescent emotional stress (ES) with the incidence of cardiovascular disease (CVD) at older age was investigated. 21 female rats were divided into three groups of 7 each; ES, foot-shock, and control. Chronic ES was induced by exposing the rats to witness foot-shock of their neighbori...

Full description

Saved in:
Bibliographic Details
Published in:Iranian journal of basic medical sciences 2019-10, Vol.22 (10), p.1179-1185
Main Authors: Mousavi, Monireh-Sadat, Imani, Alireza, Meknatkhah, Sogol, Riazi, Gholamhossein
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biophysics
Cardiovascular Disease
Emotional stress
Gender differences
Heart rate
Laboratories
M-Mode echocardiography
Natriuretic peptide receptor 3
Organic chemistry
Original
Peptides
Physiology
Protein expression
Proteins
Rodents
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Association of adolescent emotional stress (ES) with the incidence of cardiovascular disease (CVD) at older age was investigated. 21 female rats were divided into three groups of 7 each; ES, foot-shock, and control. Chronic ES was induced by exposing the rats to witness foot-shock of their neighboring counterparts in the stress-box system in 5 successive days. 6 weeks after the last stress exposure, M-Mode echocardiographic assessment, qRT-PCR, and western blotting were performed in adult rats to determine the persistent effect of adolescent ES on cardiac performance and gene/protein expression levels of cardiac natriuretic peptide receptor 3 (NPR3) as a biomarker of CVD. Interventricular septum thicknesses in diastole (IVSd) increased from 0.152±0.007 cm to 0.197±0.016 cm (
ISSN:2008-3866
2008-3874
DOI:10.22038/ijbms.2019.32888.7857