Epstein-Barr Virus-Specific Immune Control by Innate Lymphocytes

Epstein-Barr virus (EBV) is a potent B cell transforming pathogen in humans. In most persistently EBV-infected individuals, potent cytotoxic lymphocyte responses prevent EBV-associated pathologies. In addition to comprehensive adaptive T cell responses, several innate lymphocyte populations seem to...

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Bibliographic Details
Published in:Frontiers in immunology 2017-11, Vol.8, p.1658-1658
Main Author: Münz, Christian
Format: Article
Language:English
Subjects:
Immunology
infectious mononucleosis
lytic replication
natural killer cells
natural killer T cells
NKG2D
Vγ9Vδ2 T cells
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Summary:Epstein-Barr virus (EBV) is a potent B cell transforming pathogen in humans. In most persistently EBV-infected individuals, potent cytotoxic lymphocyte responses prevent EBV-associated pathologies. In addition to comprehensive adaptive T cell responses, several innate lymphocyte populations seem to target different stages of EBV infection and are compromised in primary immunodeficiencies that render individuals susceptible to symptomatic EBV infection. In this mini-review, I will highlight the functions of natural killer, γδ T cells, and natural killer T cells during innate immune responses to EBV. These innate lymphocyte populations seem to restrict both lytic replication and transforming latent EBV antigen expression. The mechanisms underlying the recognition of these different EBV infection programs by the respective innate lymphocytes are just starting to become unraveled, but will provide immunotherapeutic strategies to target pathologies that are associated with the different EBV infection programs.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2017.01658