Loading…
Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2
Artemisia argyi (A. argyi), also called Chinese mugwort, has been widely used to control pandemic diseases for thousands of years since ancient China due to its anti-microbial infection, anti-allergy, and anti-inflammation activities. Therefore, the potential of A. argyi and its constituents in redu...
Saved in:
| Published in: | Cell & bioscience 2023-06, Vol.13 (1), p.118-118, Article 118 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c598t-9962b32c1799e8d9a86c789e170283ae6ac1e672c7ab2bb4c4f68bd0c143bf303 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c598t-9962b32c1799e8d9a86c789e170283ae6ac1e672c7ab2bb4c4f68bd0c143bf303 |
| container_end_page | 118 |
| container_issue | 1 |
| container_start_page | 118 |
| container_title | Cell & bioscience |
| container_volume | 13 |
| creator | Cheng, Fang-Ju Ho, Chien-Yi Li, Tzong-Shiun Chen, Yeh Yeh, Yi-Lun Wei, Ya-Ling Huynh, Thanh Kieu Chen, Bo-Rong Ko, Hung-Yu Hsueh, Chen-Si Tan, Ming Wu, Yang-Chang Huang, Hui-Chi Tang, Chih-Hsin Chen, Chia-Hung Tu, Chih-Yen Huang, Wei-Chien |
| description | Artemisia argyi (A. argyi), also called Chinese mugwort, has been widely used to control pandemic diseases for thousands of years since ancient China due to its anti-microbial infection, anti-allergy, and anti-inflammation activities. Therefore, the potential of A. argyi and its constituents in reducing the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was investigated in this study.
Among the phytochemicals in A. argyi, eriodictyol and umbelliferone were identified to target transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2) proteins, the essential factors for the cellular entry of SARS-CoV-2, in both FRET-based enzymatic assays and molecular docking analyses. These two ingredients of A. argyi suppressed the infection of ACE2-expressed HEK-293 T cells with lentiviral-based pseudo-particles (Vpp) expressing wild-type and variants of SARS-CoV-2 spike (S) protein (SARS-CoV-2 S-Vpp) via interrupting the interaction between S protein and cellular receptor ACE2 and reducing the expressions of ACE2 and TMPRSS2. Oral administration with umbelliferone efficiently prevented the SARS-CoV-2 S-Vpp-induced inflammation in the lung tissues of BALB/c mice.
Eriodictyol and umbelliferone, the phytochemicals of Artemisia argyi, potentially suppress the cellular entry of SARS-CoV-2 by preventing the protein binding activity of the S protein to ACE2. |
| doi_str_mv | 10.1186/s13578-023-01070-y |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_aa6970c242704050bfe5835c96291324</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A755065465</galeid><doaj_id>oai_doaj_org_article_aa6970c242704050bfe5835c96291324</doaj_id><sourcerecordid>A755065465</sourcerecordid><originalsourceid>FETCH-LOGICAL-c598t-9962b32c1799e8d9a86c789e170283ae6ac1e672c7ab2bb4c4f68bd0c143bf303</originalsourceid><addsrcrecordid>eNptkk1v1DAQhiMEolXpH-CAInGBQ4o_4q8TWq2gXakSUpdytRxnsvUqiRc7QeTf43Tb0iDsg63xM6894zfL3mJ0gbHknyKmTMgCEVogjAQqphfZKUElK6hA-OWz_Ul2HuMepVGqRLLX2QkVVGLEyWl2edtV0LaugeB7yE1f5xCcr50dJt_mcTwcAsSYD3eQ2wSOrQk59EOYct_k29XNtlj7HwV5k71qTBvh_GE9y26_fvm-viquv11u1qvrwjIlh0IpTipKLBZKgayVkdwKqQALRCQ1wI3FwAWxwlSkqkpbNlxWNbK4pFVDET3LNkfd2pu9PgTXmTBpb5y-D_iw0yYMzragjeFKIEtKIlCJGKoaYJIym56gMCVl0vp81DqMVQe1ncsy7UJ0edK7O73zvzRGFJWU8aTw4UEh-J8jxEF3Ls5tMj34MepUEyZKKcIS-v4fdO_H0KdezZQUkhPC_1I7kypwfePTxXYW1SvBGOKs5LPWxX-oNGvonE3_2LgUXyR8XCQkZoDfw86MMerN9mbJkiNrg48xQPPUEIz0bD19tJ5O1tP31tNTSnr3vJVPKY9Go38ArtzPzA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2838786226</pqid></control><display><type>article</type><title>Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2</title><source>Publicly Available Content Database</source><source>PubMed Central</source><source>Coronavirus Research Database</source><creator>Cheng, Fang-Ju ; Ho, Chien-Yi ; Li, Tzong-Shiun ; Chen, Yeh ; Yeh, Yi-Lun ; Wei, Ya-Ling ; Huynh, Thanh Kieu ; Chen, Bo-Rong ; Ko, Hung-Yu ; Hsueh, Chen-Si ; Tan, Ming ; Wu, Yang-Chang ; Huang, Hui-Chi ; Tang, Chih-Hsin ; Chen, Chia-Hung ; Tu, Chih-Yen ; Huang, Wei-Chien</creator><creatorcontrib>Cheng, Fang-Ju ; Ho, Chien-Yi ; Li, Tzong-Shiun ; Chen, Yeh ; Yeh, Yi-Lun ; Wei, Ya-Ling ; Huynh, Thanh Kieu ; Chen, Bo-Rong ; Ko, Hung-Yu ; Hsueh, Chen-Si ; Tan, Ming ; Wu, Yang-Chang ; Huang, Hui-Chi ; Tang, Chih-Hsin ; Chen, Chia-Hung ; Tu, Chih-Yen ; Huang, Wei-Chien</creatorcontrib><description>Artemisia argyi (A. argyi), also called Chinese mugwort, has been widely used to control pandemic diseases for thousands of years since ancient China due to its anti-microbial infection, anti-allergy, and anti-inflammation activities. Therefore, the potential of A. argyi and its constituents in reducing the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was investigated in this study.
Among the phytochemicals in A. argyi, eriodictyol and umbelliferone were identified to target transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2) proteins, the essential factors for the cellular entry of SARS-CoV-2, in both FRET-based enzymatic assays and molecular docking analyses. These two ingredients of A. argyi suppressed the infection of ACE2-expressed HEK-293 T cells with lentiviral-based pseudo-particles (Vpp) expressing wild-type and variants of SARS-CoV-2 spike (S) protein (SARS-CoV-2 S-Vpp) via interrupting the interaction between S protein and cellular receptor ACE2 and reducing the expressions of ACE2 and TMPRSS2. Oral administration with umbelliferone efficiently prevented the SARS-CoV-2 S-Vpp-induced inflammation in the lung tissues of BALB/c mice.
Eriodictyol and umbelliferone, the phytochemicals of Artemisia argyi, potentially suppress the cellular entry of SARS-CoV-2 by preventing the protein binding activity of the S protein to ACE2.</description><identifier>ISSN: 2045-3701</identifier><identifier>EISSN: 2045-3701</identifier><identifier>DOI: 10.1186/s13578-023-01070-y</identifier><identifier>PMID: 37381062</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>ACE2 ; Allergic reaction ; Allergy ; Angiotensin ; Angiotensin-converting enzyme 2 ; Antihistamines ; Artemisia argyi ; China ; Chinese medicine ; Coronaviruses ; Coumarins ; COVID-19 ; Cytotoxicity ; Disease transmission ; Epidemics ; Eriodictyol ; Health aspects ; Infections ; Inflammation ; Lymphocytes T ; Oral administration ; Pandemics ; Peptidyl-dipeptidase A ; Phytochemicals ; Prevention ; Proteases ; Protein binding ; Proteins ; Respiratory diseases ; SARS-CoV-2 variants ; Serine proteinase ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; T cells ; TMPRSS2 ; Umbelliferone ; Viruses</subject><ispartof>Cell & bioscience, 2023-06, Vol.13 (1), p.118-118, Article 118</ispartof><rights>2023. The Author(s).</rights><rights>COPYRIGHT 2023 BioMed Central Ltd.</rights><rights>2023. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c598t-9962b32c1799e8d9a86c789e170283ae6ac1e672c7ab2bb4c4f68bd0c143bf303</citedby><cites>FETCH-LOGICAL-c598t-9962b32c1799e8d9a86c789e170283ae6ac1e672c7ab2bb4c4f68bd0c143bf303</cites><orcidid>0000-0001-6467-8716</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304356/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2838786226?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,38516,43895,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37381062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Fang-Ju</creatorcontrib><creatorcontrib>Ho, Chien-Yi</creatorcontrib><creatorcontrib>Li, Tzong-Shiun</creatorcontrib><creatorcontrib>Chen, Yeh</creatorcontrib><creatorcontrib>Yeh, Yi-Lun</creatorcontrib><creatorcontrib>Wei, Ya-Ling</creatorcontrib><creatorcontrib>Huynh, Thanh Kieu</creatorcontrib><creatorcontrib>Chen, Bo-Rong</creatorcontrib><creatorcontrib>Ko, Hung-Yu</creatorcontrib><creatorcontrib>Hsueh, Chen-Si</creatorcontrib><creatorcontrib>Tan, Ming</creatorcontrib><creatorcontrib>Wu, Yang-Chang</creatorcontrib><creatorcontrib>Huang, Hui-Chi</creatorcontrib><creatorcontrib>Tang, Chih-Hsin</creatorcontrib><creatorcontrib>Chen, Chia-Hung</creatorcontrib><creatorcontrib>Tu, Chih-Yen</creatorcontrib><creatorcontrib>Huang, Wei-Chien</creatorcontrib><title>Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2</title><title>Cell & bioscience</title><addtitle>Cell Biosci</addtitle><description>Artemisia argyi (A. argyi), also called Chinese mugwort, has been widely used to control pandemic diseases for thousands of years since ancient China due to its anti-microbial infection, anti-allergy, and anti-inflammation activities. Therefore, the potential of A. argyi and its constituents in reducing the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was investigated in this study.
Among the phytochemicals in A. argyi, eriodictyol and umbelliferone were identified to target transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2) proteins, the essential factors for the cellular entry of SARS-CoV-2, in both FRET-based enzymatic assays and molecular docking analyses. These two ingredients of A. argyi suppressed the infection of ACE2-expressed HEK-293 T cells with lentiviral-based pseudo-particles (Vpp) expressing wild-type and variants of SARS-CoV-2 spike (S) protein (SARS-CoV-2 S-Vpp) via interrupting the interaction between S protein and cellular receptor ACE2 and reducing the expressions of ACE2 and TMPRSS2. Oral administration with umbelliferone efficiently prevented the SARS-CoV-2 S-Vpp-induced inflammation in the lung tissues of BALB/c mice.
Eriodictyol and umbelliferone, the phytochemicals of Artemisia argyi, potentially suppress the cellular entry of SARS-CoV-2 by preventing the protein binding activity of the S protein to ACE2.</description><subject>ACE2</subject><subject>Allergic reaction</subject><subject>Allergy</subject><subject>Angiotensin</subject><subject>Angiotensin-converting enzyme 2</subject><subject>Antihistamines</subject><subject>Artemisia argyi</subject><subject>China</subject><subject>Chinese medicine</subject><subject>Coronaviruses</subject><subject>Coumarins</subject><subject>COVID-19</subject><subject>Cytotoxicity</subject><subject>Disease transmission</subject><subject>Epidemics</subject><subject>Eriodictyol</subject><subject>Health aspects</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Lymphocytes T</subject><subject>Oral administration</subject><subject>Pandemics</subject><subject>Peptidyl-dipeptidase A</subject><subject>Phytochemicals</subject><subject>Prevention</subject><subject>Proteases</subject><subject>Protein binding</subject><subject>Proteins</subject><subject>Respiratory diseases</subject><subject>SARS-CoV-2 variants</subject><subject>Serine proteinase</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>T cells</subject><subject>TMPRSS2</subject><subject>Umbelliferone</subject><subject>Viruses</subject><issn>2045-3701</issn><issn>2045-3701</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>COVID</sourceid><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1v1DAQhiMEolXpH-CAInGBQ4o_4q8TWq2gXakSUpdytRxnsvUqiRc7QeTf43Tb0iDsg63xM6894zfL3mJ0gbHknyKmTMgCEVogjAQqphfZKUElK6hA-OWz_Ul2HuMepVGqRLLX2QkVVGLEyWl2edtV0LaugeB7yE1f5xCcr50dJt_mcTwcAsSYD3eQ2wSOrQk59EOYct_k29XNtlj7HwV5k71qTBvh_GE9y26_fvm-viquv11u1qvrwjIlh0IpTipKLBZKgayVkdwKqQALRCQ1wI3FwAWxwlSkqkpbNlxWNbK4pFVDET3LNkfd2pu9PgTXmTBpb5y-D_iw0yYMzragjeFKIEtKIlCJGKoaYJIym56gMCVl0vp81DqMVQe1ncsy7UJ0edK7O73zvzRGFJWU8aTw4UEh-J8jxEF3Ls5tMj34MepUEyZKKcIS-v4fdO_H0KdezZQUkhPC_1I7kypwfePTxXYW1SvBGOKs5LPWxX-oNGvonE3_2LgUXyR8XCQkZoDfw86MMerN9mbJkiNrg48xQPPUEIz0bD19tJ5O1tP31tNTSnr3vJVPKY9Go38ArtzPzA</recordid><startdate>20230628</startdate><enddate>20230628</enddate><creator>Cheng, Fang-Ju</creator><creator>Ho, Chien-Yi</creator><creator>Li, Tzong-Shiun</creator><creator>Chen, Yeh</creator><creator>Yeh, Yi-Lun</creator><creator>Wei, Ya-Ling</creator><creator>Huynh, Thanh Kieu</creator><creator>Chen, Bo-Rong</creator><creator>Ko, Hung-Yu</creator><creator>Hsueh, Chen-Si</creator><creator>Tan, Ming</creator><creator>Wu, Yang-Chang</creator><creator>Huang, Hui-Chi</creator><creator>Tang, Chih-Hsin</creator><creator>Chen, Chia-Hung</creator><creator>Tu, Chih-Yen</creator><creator>Huang, Wei-Chien</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-6467-8716</orcidid></search><sort><creationdate>20230628</creationdate><title>Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2</title><author>Cheng, Fang-Ju ; Ho, Chien-Yi ; Li, Tzong-Shiun ; Chen, Yeh ; Yeh, Yi-Lun ; Wei, Ya-Ling ; Huynh, Thanh Kieu ; Chen, Bo-Rong ; Ko, Hung-Yu ; Hsueh, Chen-Si ; Tan, Ming ; Wu, Yang-Chang ; Huang, Hui-Chi ; Tang, Chih-Hsin ; Chen, Chia-Hung ; Tu, Chih-Yen ; Huang, Wei-Chien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c598t-9962b32c1799e8d9a86c789e170283ae6ac1e672c7ab2bb4c4f68bd0c143bf303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>ACE2</topic><topic>Allergic reaction</topic><topic>Allergy</topic><topic>Angiotensin</topic><topic>Angiotensin-converting enzyme 2</topic><topic>Antihistamines</topic><topic>Artemisia argyi</topic><topic>China</topic><topic>Chinese medicine</topic><topic>Coronaviruses</topic><topic>Coumarins</topic><topic>COVID-19</topic><topic>Cytotoxicity</topic><topic>Disease transmission</topic><topic>Epidemics</topic><topic>Eriodictyol</topic><topic>Health aspects</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Lymphocytes T</topic><topic>Oral administration</topic><topic>Pandemics</topic><topic>Peptidyl-dipeptidase A</topic><topic>Phytochemicals</topic><topic>Prevention</topic><topic>Proteases</topic><topic>Protein binding</topic><topic>Proteins</topic><topic>Respiratory diseases</topic><topic>SARS-CoV-2 variants</topic><topic>Serine proteinase</topic><topic>Severe acute respiratory syndrome</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>T cells</topic><topic>TMPRSS2</topic><topic>Umbelliferone</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Fang-Ju</creatorcontrib><creatorcontrib>Ho, Chien-Yi</creatorcontrib><creatorcontrib>Li, Tzong-Shiun</creatorcontrib><creatorcontrib>Chen, Yeh</creatorcontrib><creatorcontrib>Yeh, Yi-Lun</creatorcontrib><creatorcontrib>Wei, Ya-Ling</creatorcontrib><creatorcontrib>Huynh, Thanh Kieu</creatorcontrib><creatorcontrib>Chen, Bo-Rong</creatorcontrib><creatorcontrib>Ko, Hung-Yu</creatorcontrib><creatorcontrib>Hsueh, Chen-Si</creatorcontrib><creatorcontrib>Tan, Ming</creatorcontrib><creatorcontrib>Wu, Yang-Chang</creatorcontrib><creatorcontrib>Huang, Hui-Chi</creatorcontrib><creatorcontrib>Tang, Chih-Hsin</creatorcontrib><creatorcontrib>Chen, Chia-Hung</creatorcontrib><creatorcontrib>Tu, Chih-Yen</creatorcontrib><creatorcontrib>Huang, Wei-Chien</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Science in Context</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Cell & bioscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Fang-Ju</au><au>Ho, Chien-Yi</au><au>Li, Tzong-Shiun</au><au>Chen, Yeh</au><au>Yeh, Yi-Lun</au><au>Wei, Ya-Ling</au><au>Huynh, Thanh Kieu</au><au>Chen, Bo-Rong</au><au>Ko, Hung-Yu</au><au>Hsueh, Chen-Si</au><au>Tan, Ming</au><au>Wu, Yang-Chang</au><au>Huang, Hui-Chi</au><au>Tang, Chih-Hsin</au><au>Chen, Chia-Hung</au><au>Tu, Chih-Yen</au><au>Huang, Wei-Chien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2</atitle><jtitle>Cell & bioscience</jtitle><addtitle>Cell Biosci</addtitle><date>2023-06-28</date><risdate>2023</risdate><volume>13</volume><issue>1</issue><spage>118</spage><epage>118</epage><pages>118-118</pages><artnum>118</artnum><issn>2045-3701</issn><eissn>2045-3701</eissn><abstract>Artemisia argyi (A. argyi), also called Chinese mugwort, has been widely used to control pandemic diseases for thousands of years since ancient China due to its anti-microbial infection, anti-allergy, and anti-inflammation activities. Therefore, the potential of A. argyi and its constituents in reducing the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was investigated in this study.
Among the phytochemicals in A. argyi, eriodictyol and umbelliferone were identified to target transmembrane serine protease 2 (TMPRSS2) and angiotensin-converting enzyme 2 (ACE2) proteins, the essential factors for the cellular entry of SARS-CoV-2, in both FRET-based enzymatic assays and molecular docking analyses. These two ingredients of A. argyi suppressed the infection of ACE2-expressed HEK-293 T cells with lentiviral-based pseudo-particles (Vpp) expressing wild-type and variants of SARS-CoV-2 spike (S) protein (SARS-CoV-2 S-Vpp) via interrupting the interaction between S protein and cellular receptor ACE2 and reducing the expressions of ACE2 and TMPRSS2. Oral administration with umbelliferone efficiently prevented the SARS-CoV-2 S-Vpp-induced inflammation in the lung tissues of BALB/c mice.
Eriodictyol and umbelliferone, the phytochemicals of Artemisia argyi, potentially suppress the cellular entry of SARS-CoV-2 by preventing the protein binding activity of the S protein to ACE2.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>37381062</pmid><doi>10.1186/s13578-023-01070-y</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6467-8716</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-3701 |
| ispartof | Cell & bioscience, 2023-06, Vol.13 (1), p.118-118, Article 118 |
| issn | 2045-3701 2045-3701 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_aa6970c242704050bfe5835c96291324 |
| source | Publicly Available Content Database; PubMed Central; Coronavirus Research Database |
| subjects | ACE2 Allergic reaction Allergy Angiotensin Angiotensin-converting enzyme 2 Antihistamines Artemisia argyi China Chinese medicine Coronaviruses Coumarins COVID-19 Cytotoxicity Disease transmission Epidemics Eriodictyol Health aspects Infections Inflammation Lymphocytes T Oral administration Pandemics Peptidyl-dipeptidase A Phytochemicals Prevention Proteases Protein binding Proteins Respiratory diseases SARS-CoV-2 variants Serine proteinase Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 T cells TMPRSS2 Umbelliferone Viruses |
| title | Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2 |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T01%3A43%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Umbelliferone%20and%20eriodictyol%20suppress%20the%20cellular%20entry%20of%20SARS-CoV-2&rft.jtitle=Cell%20&%20bioscience&rft.au=Cheng,%20Fang-Ju&rft.date=2023-06-28&rft.volume=13&rft.issue=1&rft.spage=118&rft.epage=118&rft.pages=118-118&rft.artnum=118&rft.issn=2045-3701&rft.eissn=2045-3701&rft_id=info:doi/10.1186/s13578-023-01070-y&rft_dat=%3Cgale_doaj_%3EA755065465%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c598t-9962b32c1799e8d9a86c789e170283ae6ac1e672c7ab2bb4c4f68bd0c143bf303%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2838786226&rft_id=info:pmid/37381062&rft_galeid=A755065465&rfr_iscdi=true |