Design, Preparation, and Evaluation of a Novel 99mTcN Complex of Ciprofloxacin Xanthate as a Potential Bacterial Infection Imaging Agent

In order to seek novel technetium-99m bacterial infection imaging agents, a ciprofloxacin xanthate (CPF2XT) was synthesized and radiolabeled with [99mTcN]2+ core to obtain the 99mTcN-CPF2XT complex, which exhibited high radiochemical purity, hydrophilicity, and good stability in vitro. The bacteria...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2020-12, Vol.25 (24), p.5837
Main Authors: Fang, Si’an, Jiang, Yuhao, Gan, Qianqian, Ruan, Qing, Xiao, Di, Zhang, Junbo
Format: Article
Language:English
Subjects:
99mTc-radiolabeling
Abscesses
Antibiotics
Bacteria
Bacterial diseases
Bacterial infections
Ciprofloxacin
ciprofloxacin xanthate
Imaging
infection imaging
Infections
Inflammation
Labeling
Ligands
Magnetic resonance imaging
Muscles
Nuclear medicine
quinolones
Radiochemistry
Sulfur
Technetium
Technetium isotopes
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Summary:In order to seek novel technetium-99m bacterial infection imaging agents, a ciprofloxacin xanthate (CPF2XT) was synthesized and radiolabeled with [99mTcN]2+ core to obtain the 99mTcN-CPF2XT complex, which exhibited high radiochemical purity, hydrophilicity, and good stability in vitro. The bacteria binding assay indicated that 99mTcN-CPF2XT had specificity to bacteria. A study of biodistribution in mice showed that 99mTcN-CPF2XT had a higher uptake in bacterial infection tissues than in turpentine-induced abscesses, indicating that it could distinguish bacterial infection from sterile inflammation. Compared to 99mTcN-CPFXDTC, the abscess/blood and abscess/muscle ratios of 99mTcN-CPF2XT were higher and the uptakes of 99mTcN-CPF2XT in the liver and lung were obviously decreased. The results suggested that 99mTcN-CPF2XT would be a potential bacterial infection imaging agent.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25245837