From Discovery to Production: Biotechnology of Marine Fungi for the Production of New Antibiotics

Filamentous fungi are well known for their capability of producing antibiotic natural products. Recent studies have demonstrated the potential of antimicrobials with vast chemodiversity from marine fungi. Development of such natural products into lead compounds requires sustainable supply. Marine bi...

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Bibliographic Details
Published in:Marine drugs 2016-07, Vol.14 (7), p.137
Main Authors: Silber, Johanna, Kramer, Annemarie, Labes, Antje, Tasdemir, Deniz
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - metabolism
biological derivatisation
Biological Products - metabolism
bioprocess development
Biotechnology - methods
downstream processing
filamentous fungi
full fermentative process
Fungi - metabolism
genetic and metabolic engineering
heterologous expression
Humans
marine biotechnology
Metabolic Engineering - methods
Review
semi-synthesis
transfer to stirred tank reactor
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Summary:Filamentous fungi are well known for their capability of producing antibiotic natural products. Recent studies have demonstrated the potential of antimicrobials with vast chemodiversity from marine fungi. Development of such natural products into lead compounds requires sustainable supply. Marine biotechnology can significantly contribute to the production of new antibiotics at various levels of the process chain including discovery, production, downstream processing, and lead development. However, the number of biotechnological processes described for large-scale production from marine fungi is far from the sum of the newly-discovered natural antibiotics. Methods and technologies applied in marine fungal biotechnology largely derive from analogous terrestrial processes and rarely reflect the specific demands of the marine fungi. The current developments in metabolic engineering and marine microbiology are not yet transferred into processes, but offer numerous options for improvement of production processes and establishment of new process chains. This review summarises the current state in biotechnological production of marine fungal antibiotics and points out the enormous potential of biotechnology in all stages of the discovery-to-development pipeline. At the same time, the literature survey reveals that more biotechnology transfer and method developments are needed for a sustainable and innovative production of marine fungal antibiotics.
ISSN:1660-3397
1660-3397
DOI:10.3390/md14070137