Prediction of Ischemic Events after Percutaneous Coronary Intervention: Thrombelastography Profiles and Factor XIIIa Activity

Abstract Background  High plasma fibrin clot strength (MA) measured by thrombelastography (TEG) is associated with increased risk of cardiac events after percutaneous coronary interventions (PCIs). Factor XIIIa (FXIIIa) cross-links soluble fibrin, shortens clot formation time (TEG-K), and increases...

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Published in:TH open : companion journal to thrombosis and haemostasis 2018-04, Vol.2 (2), p.e173-e181
Main Authors: Kreutz, Rolf P., Schmeisser, Glen, Schaffter, Andrea, Kanuri, Sri, Owens, Janelle, Maatman, Benjamin, Sinha, Anjan, von der Lohe, Elisabeth, Breall, Jeffrey A.
Format: Article
Language:English
Subjects:
factor xiii
fibrin
myocardial infarction
Original
Original Article
percutaneous coronary intervention
thrombelastography
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Summary:Abstract Background  High plasma fibrin clot strength (MA) measured by thrombelastography (TEG) is associated with increased risk of cardiac events after percutaneous coronary interventions (PCIs). Factor XIIIa (FXIIIa) cross-links soluble fibrin, shortens clot formation time (TEG-K), and increases final clot strength (MA). Methods  We analyzed platelet-poor plasma from patients with previous PCI. Kaolin-activated TEG (R, K, MA) in citrate platelet-poor plasma and FXIIIa were measured ( n  = 257). Combined primary endpoint was defined as recurrent myocardial infarction (MI) or cardiovascular death (CVD). Relationship of FXIIIa and TEG measurements on cardiac risk was explored. Results  FXIIIa correlated with TEG-MA ( p  = 0.002) and inversely with TEG-K ( p  
ISSN:2512-9465
2567-3459
2512-9465
DOI:10.1055/s-0038-1645876