Autoinflammatory Mechanisms in Crystal-Induced Arthritis

Crystal-induced arthritides have been classified as "type-1 autoinflammatory diseases" for their main features which resemble those of the monogenic autoinflammatory syndromes. They are in fact characterized by spontaneous onset, recurrence of the episodes, self-limitation and resolution,...

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Bibliographic Details
Published in:Frontiers in medicine 2020-04, Vol.7, p.166-166
Main Authors: Oliviero, Francesca, Bindoli, Sara, Scanu, Anna, Feist, Eugen, Doria, Andrea, Galozzi, Paola, Sfriso, Paolo
Format: Article
Language:English
Subjects:
autoinflammatory disease
crystal-induced arthritis
inflammasome
interleukin-1
interleukin-1 receptor antagonist
Medicine
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Summary:Crystal-induced arthritides have been classified as "type-1 autoinflammatory diseases" for their main features which resemble those of the monogenic autoinflammatory syndromes. They are in fact characterized by spontaneous onset, recurrence of the episodes, self-limitation and resolution, inflammasome activation with huge production of IL-1β and a prevalent involvement of the innate immune system. The term "auto" refers also to the induction of IL-1β gene expression, processing and secretion by IL-1β itself. The concept of autoinflammation in crystal-induced arthritis has been finally reinforced by the efficacy of IL-1 blockade in treating acute and chronic state of this disease. The aim of this article is to review the autoinflammatory mechanisms in crystal-induced arthritis, considering both clinical and molecular aspects.
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2020.00166