MYCN Function in Neuroblastoma Development

Dysregulated expression of the transcription factor MYCN is frequently detected in nervous system tumors such as childhood neuroblastoma. Here, gene amplification of is a single oncogenic driver inducing neoplastic transformation in neural crest-derived cells. This abnormal expression is one of the...

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Bibliographic Details
Published in:Frontiers in oncology 2021-01, Vol.10, p.624079-624079
Main Authors: Otte, Jörg, Dyberg, Cecilia, Pepich, Adena, Johnsen, John Inge
Format: Article
Language:English
Subjects:
cancer stem cell
childhood cancer
MYCN
neural crest
neuroblastoma
Oncology
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Summary:Dysregulated expression of the transcription factor MYCN is frequently detected in nervous system tumors such as childhood neuroblastoma. Here, gene amplification of is a single oncogenic driver inducing neoplastic transformation in neural crest-derived cells. This abnormal expression is one of the strongest predictors of poor prognosis. It is present at diagnosis and is never acquired during later tumorigenesis of non-amplified neuroblastoma. This suggests that increased expression is an early event in these cancers leading to a peculiar dysregulation of cells that results in embryonal or cancer stem-like qualities, such as increased self-renewal, apoptotic resistance, and metabolic flexibility.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2020.624079