Influence of TNF-α inhibition on oxidative stress of rheumatoid arthritis patients

• Published in: Reumatismo 2015-12, Vol.67 (3), p.97-102
• Main Authors: Cacciapaglia, F, Anelli, M G, Rizzo, D, Morelli, E, Scioscia, C, Mazzotta, D, Iannone, F, Lapadula, G
• Format: Article
• Language: English
• Subjects: Adult; Aged; Anti-TNF; Antirheumatic Agents - therapeutic use; Arthritis, Rheumatoid - blood; Arthritis, Rheumatoid - drug therapy; Biomarkers - blood; C-Reactive Protein - metabolism; Female; Humans; Hydrogen Peroxide - metabolism; Male; Middle Aged; Oxidants - metabolism; Oxidative stress; Oxidative Stress - drug effects; reactive oxygen species; Rheumatoid arthritis; Tumor Necrosis Factor-alpha - antagonists & inhibitors; Tumor necrosis factor-TNF
• ISSN: 0048-7449; 2240-2683
• DOI: 10.4081/reumatismo.2015.829

The aim of this study was to assess circulating levels of reactive oxygen metabolites (ROMs) as a marker of oxidative stress in rheumatoid arthritis (RA) patients during an anti-tumor necrosis factor alpha (TNF-α) treatment. We enrolled 40 patients with RA (36 females; age 53 ± 13 yrs) treated with different subcutaneously administered TNF-α inhibitors. The oxidative status was determined on the basis of plasma samples taken before, at 24 and 52 weeks of the anti-TNF-α treatment. Hydroperoxide levels were measured using the d-ROMs test, a useful clinically proven oxidative stress marker. During the anti-TNF-α therapy, we observed a significant reduction in serum ROMs levels in RA patients from 33.2 ± 10 mg H2O2/L at baseline to 29.5 ± 7 and 29.3 ± 9 mg H2O2/L, at 24 and 52 weeks, respectively (p